Indian Association for the Cultivation of Science
» Structure and Dynamics: Spectroscopy and Scattering (SDSS - 2023) » Hybrid Halide Perovskites 2023 » Notice No. 3.032/1032 dated 29.08.2023 on re-constitution of the Management Committee of IACS » Special Campaign 3.0 mandated by DST » DST Notification » Quantum Sensing & Quantum Metrology » A Conference on "Recent Trends In Condensed Matter Physics Related To Quantum Materials" » IACS Colloquium from the School of Physical Sciences by Prof. Anindya Das, Department of Physics, Indian Institute of Science, Bangalore on 23rd February 2024 (Friday) » International Conference on Catalysis (IC²-2024) » 75th Republic Day Celebration at IACS Premises on 26.01.2024 » National Science Day celebration at IACS on 28th February, 2024 » IACS Colloquium from School of Physical Sciences by Prof. Diptiman Sen, IISc Bangalore » SAIS Symposium 2024 on 1st & 2nd March 2024 » Admission to Integrated Bachelor's-Master's Program in Science and Master's/Integrated Master's-Ph.D. Program in Science - 2024 » Appointment of one Sports Officer on purely temporary and contractual basis (in Consultancy mode) initially for a period of two (2) years. » Last date of Applications/Nominations for appointment of Director has been extended up-to 30th April, 2024 » Admission to the joint M.Sc.-Ph.D. Program in “Chemical and Molecular Biology” for the academic year 2024-25 (IACS and IIT-KGP) » Observance of Swachhata Pakhwada-2024 at IACS from May 01,2024 to May 15,2024. » Schedule of Interview for PhD Admission (Autumn Semester 2024) for School of Applied and Interdisciplinary Sciences(SAIS) » Notice for in-operative PAN » Schedule of Interview for PhD Admission (Autumn Semester 2024)for School of Biological Sciences(SBS) » Schedule of Interview for PhD Admission (Autumn Semester 2024)for School of Chemical Sciences(SCS) » Schedule of Interview for PhD Admission (Autumn Semester 2024)for School of Mathematical and Computational Sciences (SMCS) » Schedule of Interview for PhD Admission (Autumn Semester 2024)for School of Physical Sciences (SPS)

Name : Prosenjit Sen

Department : School of Biological Sciences
Designation : Professor
Contact : +91 33 2473 4971 (Ext:1518)
Email : bcps@iacs.res.in


Home

  Focus of the laboratory is to understand the coagulation-cancer interface using computational drug designing, molecular dynamic simulation; chemical synthesis of various compounds (small group inhibitors, various phospholipids, etc), molecular biology techniques and to find its involvement with signaling pathways in cancer progression. Our other interest includes signaling associated with monocyte  to macrophage differentiation.

 


Academic Profile

Academic Profile

  • Associate Professor Since Sep.2017: IACS, Kolkata
  • Assistant Professor (Feb.2012-Sep2017): IACS, Kolkata
  •  Post-Doc (2007-2012): UTHSCT, USA (Coagulation Biology)
  •  PhD (2007): SINP, Kolkata (Cell Signaling & Apoptosis)
  •  Post-M.Sc. (2000): SINP, Kolkata (Biophysical Science)
  •  M.Sc. (1999): Calcutta University (Organic Chemistry)
  •  B.Sc. (1997): DA College, Calcutta University (Chemistry)


Group

SUPARNA BANERJEE


CSIR- SRF
MSC IN BIOTECHNOLOGY AND BIOINFORMATICS
DRUG DESIGNING AND COAGULATION/ANTICOAGULATION REGULATION
bcsb7@iacs.res.in
ARPANA SINGH


SRF - DST INSPIRE
M.Sc IN HUMAN PHYSIOLOGY
MONOCYTE TO MACROPHAGE DIFFERENTIATION IN CONTEXT OF LIPID-DROPLETS
bcas@iacs.res.in
SUBHASIS MANDAL


SRF- Institute Fellow
M.Sc in Chemistry
Organic synthesis and their biological applications.
intsbm@iacs.res.in
ARNAB GHOSH


CSIR- SRF
MSc. in Human Physiology
Coagulation factors and immune-editing.
bcag3@iacs.res.in
SUBHOJIT PAUL


CSIR- SRF
MSc. in Zoology
Role of Exosomes in Cancer Propagation
bcsp3@iacs.res.in
Avinandan Bhoumick

CSIR-JRF
M.Sc in Microbiology
Bioactive lipids and cancer immune evasion
sbsab2532@iacs.res.in
Akash Chatterjee

Institute Fellow
M. Sc in Applied and interdisciplinary science
Cancer immunology
aisac2410@iacs.res.in

 


Publication

Publications

 

Subhasis Mandal, Arpana Singh, Subhojit Paul, Arnab Ghosh and Prosenjit Sen Amino    acid    triggered    water-soluble    NBD    derivatives    for differential organelle staining and the role of the chemical moiety for their specific localization. Chemistry - An Asian Journal (2022) doi.org/10.1002/asia.202200837

 

Arpana Singh, Kaushik Das, Sampali Banerjee, Prosenjit Sen Elucidation of signalling pathways for enhanced exosome release from Mycobacterium infected macrophages and subsequent induction of differentiation. Immunology (2022) doi.org/10.1111/imm.13561

 

Subir Paul, Anindita Bhattacharya, Niladri Hazra, Kousik Gayen, Prosenjit Sen, and Arindam Banerjee Yellow-Emitting Carbon Dots for Selective Fluorescence Imaging of Lipid Droplets in Living Cells langmuir (ACS) (2022)  38, 29, 8829–8836

 

 Mahuya Kar, Md Anas, Palash Banerjee, Arpana Singh, Prosenjit Sen, and Tarun k. Mandal Amphiphilic Perylene Bisimide-Polymer Conjugates by Cystein –Based Orthogonal Strategy: vascular Aggregation , DNA binding, and Cell Imaging. , ACS Appl.Polym.Mater (2022),4,5,3697-3710

 

 

Anindita Bhattacharya, Purnam Ghosh, Arpana Singh, Arnab Ghosh, Arghya Bhowmick, Deepak Kumar Sinha,  Abhrajyoti Ghosh, Prosenjit Sen*Delineating the complex mechanistic interplay between NF- kb  driven mTOR dependent autophagy and monocyte to macrophage differentiation: a functional perspective. Cellular Signalling  88 (2021) 110150

 

Arpana Singh, Prosenjit Sen Lipid droplet: A functionally active organelle in monocyte to macrophage differentiation and its inflammatory properties  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Volume 1866, Issue 10, October 2021, 158981

 

 Sayantan Pradhan, Ramesh Prasad, Chittaranjan Sinha , Prosenjit Sen Molecular modeling of potent novel sulfonamide derivatives as non-peptide small molecule anti-COVID 19 agents.  (2021) Journal of Biomolecular Structure and Dynamics. https://doi.org/10.1080/07391102.2021.1897043

 

Suman Malik, Ramesh Prasad,Kaushik Das, Prosenjit Sen Alcohol functionality in the fatty acid backbone of sphingomyelin guides the inhibition of blood coagulation.  RSC Advance DOI: 10.1039/D0RA09218E  2021, 11, 3390-3398

 

 

Anindita Bhattacharya, Purnam Ghosh, Ramesh Prasad, Arnab Ghosh, Kaushik Das, Abhishek Roy, Suman Mallik, Deepak Kumar Sinha,  Prosenjit Sen* MAP Kinase driven actomyosin rearrangement is a crucial regulator of monocyte to macrophage differentiation,, Cellular Signalling  73 (2020) 109691

 

Joyanta Mondal, Ruma Sarkar, Prosenjit Sen* and Rajib Kumar Goswami*Total Synthesis and Stereochemical Assignment of Sunshinamide and Its Anticancer Activity  Organic Letters, 22, 1188−1192 (2020)

 

Kaushik Das.Subhojit Paul, Arpana Singh, Arnab Ghosh, Abhishek Roy, Shabbir Ahmed Ansari, Ramesh Prasad, Ashis Mukherjee and Prosenjit Sen. Triple negative breast cancer-derived microvesicles transfer microRNA221 to the recipient cells and thereby promote epithelial-to-mesenchymal transition. J Biol Chem  July 24,2019 294(37) 13681–13696 doi: 10.1074/jbc.RA119.008619.(American Society for Biochemistry and Molecular Biology journal)

 

Banerjee S., Prasad R. and Sen P. In silico mutation and binding studies of human FVIIa GLA-domain to endothelial protein C receptor: A molecular dynamics simulation approach. ACS Omega (2019), 4, 496−508 DOI: 10.1021/acsomega.8b02647

 

Bhattacharya#, A., Agarwal#, M., Mukherjee, R., Sen, P., Sinha, D.K. 3D micro-environment regulates NF-kβ dependent adhesion to induce monocyte differentiation. Cell Death & Disease (2018)  (Nature Journal) (2018) 9:914 DOI 10.1038/s41419-018-0993-z

 

Prasad, R. & Sen, P. Phosphatidylcholine in the Groove of Endothelial cell protein C receptor (EPCR) regulates EPCR conformation and Protein C recognition. Integrative Biology (2018).DOI:10.1039/C8IB00115D  (Royal Society of Chemistry)

 

Prasad, R., Banerjee, S., & Sen, P. Contribution of allosteric disulfide in the structural regulation of membrane-bound tissue factor-factor VIIa binary complex. J Biomol Struct Dyn (2018). https://doi.org/10.1080/07391102.2018.1526118(Taylor & Francis Group)

 

Das K, Prasad R, Singh A, Bhattacharya A, Roy A, Mallik S, ..& Sen P. Protease-Activated Receptor2 promotes actomyosin dependent transforming microvesicles generation from human breast cancer. Mol Carcinogenesis. 2018.doi:10.1002/mc.22891.(Wiley Journal)

 

Das, K., Prasad, R., Ansari, S.A., Roy, A., Mukherjee, A. & Sen, P. Matrix metalloproteinase-2: A key regulator in coagulation proteases mediated human breast cancer progression through autocrine signaling. Biomedicine & Pharmacotherapy 2018; 105: 395-406. (Elsevier journal)

 

Das, K., Prasad, R., Roy, S., Mukherjee, A. & Sen, P. The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles. Sci Rep 2018; 8: 7357.(Nature journal)

 

Mallik, S., Prasad, R., Bhattacharya, A. & Sen, P. Synthesis of Phosphatidylserine and Its Stereoisomers: Their Role in Activation of Blood Coagulation. ACS Med Chem Lett 2018; 9: 434–439.(American Chemical Society)

 

Prasad R, Sen P. Molecular determinants involved in differential behaviour between soluble tissue factor and full-length tissue factor towards factor VIIa. Phys Chem Chem Phys 2017; 19: 22230–22242. (Royal Society Of Chemistry)

 

Roy A, Ansari SA, Das K, Prasad R, Bhattacharya A, Mallik S, Sen P. Coagulation factor VIIa-mediated protease-activated receptor 2 activation leads to β-catenin accumulation via the AKT/GSK3β pathway and contributes to breast cancer progression. J Biol Chem 2017; 292: 13688–13701.(American Society for Biochemistry and Molecular Biology journal)

 

Prasad R, Sen P. Structural modulation of factor VIIa by full-length tissue factor (TF1-263): implication of novel interactions between EGF2 domain and TF. J Biomol Struct Dyn 2018; 36: 621–633. (Taylor & Francis Group.Journal)

 

Ansari SA, Pendurthi UR, Sen P, Rao LVM. The Role of Putative Phosphatidylserine-Interactive Residues of Tissue Factor on Its Coagulant Activity at the Cell Surface. PLoS One 2016; 11: e0158377.(Public Library of Science Journal)

 

Datta D, Aftabuddin M, Gupta DK, Raha S, Sen P. Human Prostate Cancer Hallmarks Map. Sci Rep 2016; 6: 30691.(Nature journal)

 

Sen P, Clark CA, Gopalakrishnan R, Hedner U, Esmon CT, Pendurthi UR et al. Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systems. Thromb Haemost 2012; 107: 951–961.

 

Sen P, Nayak R, Clark CA, Gopalakrishnan R, Esmon CT, Pendurthi UR et al. Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. Blood 2011; 118: 2635–6.(American Society of Hematology)

 

Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT et al. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood 2011; 117: 3199–208.(American Society of Hematology)

 

Sen P, Komissarov AA, Florova G, Idell S, Pendurthi UR, Vijaya Mohan Rao L. Plasminogen activator inhibitor-1 inhibits factor VIIa bound to tissue factor. J Thromb Haemost 2011; 9: 531–9.(Wiley Journal)

 

Sen P, Sahoo S, Pendurthi UR, Rao LVM. Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor. J Biol Chem 2010; 285: 20410–20. (American Society for Biochemistry and Molecular Biology journal)

 

Sen P, Ghosh S, Ezban M, Pendurthi UR, Vijaya Mohan Rao L. Effect of glycoPEGylation on factor VIIa binding and internalization. Haemophilia 2010; 16: 339–48.(Wiley Journal)

 

Sen P, Neuenschwander PF, Pendurthi UR, Rao LVM. Analysis of factor VIIa binding to relipidated tissue factor by surface plasmon resonance. Blood Coagul Fibrinolysis 2010; 21: 376–9.(Wolters Kluwer Journal)

 

Nayak RC, Sen P, Ghosh S, Gopalakrishnan R, Esmon CT, Pendurthi UR et al. Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications. Blood 2009; 114: 1974–86.(American Society of Hematology)

 

Kothari H, Sen P, Pendurthi UR, Rao LVM. Bovine protein disulfide isomerase-enhanced tissue factor coagulant function: is phospholipid contaminant in it the real culprit? Blood 2008; 111: 3295–6.(American Society of Hematology)

 

Ghosh S, Sen P, Pendurthi UR, Rao LVM, Rao LVM. Activity and regulation of glycoPEGylated factor VIIa analogs. J Thromb Haemost 2008; 6: 1525–33.(Wiley Journal)

 

Mookerjee Basu J, Mookerjee A, Sen P, Bhaumik S, Sen P, Banerjee S et al. Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages. Antimicrob Agents Chemother 2006; 50: 1788–97.

 

Sen P, Chakraborty PK, Raha S. Tea polyphenol epigallocatechin 3-gallate impedes the anti-apoptotic effects of low-grade repetitive stress through inhibition of Akt and NFkappaB survival pathways. FEBS Lett 2006; 580: 278–84.(John Wiley & sons publication)

 

Sen P, Chakraborty PK, Raha S. p38 mitogen-activated protein kinase (p38MAPK) upregulates catalase levels in response to low dose H2O2 treatment through enhancement of mRNA stability. FEBS Lett 2005; 579: 4402–6.(John Wiley & sons publication)

 

Sen P, Mukherjee S, Bhaumik G, Das P, Ganguly S, Choudhury N et al. Enhancement of catalase activity by repetitive low-grade H2O2 exposures protects fibroblasts from subsequent stress-induced apoptosis. Mutat Res 2003; 529: 87–94.(Elsevier Journal)

 

Bagchi-Mukherjee, S., Sen P., Bhaumik, G., Choudhury, N., & Raha S. Inhibition of epidermal growth factor response in V79 fibroblasts after repetitive oxidative stress. Curr Sci 2003; 84: 438–443.

 

Sen P, Mukherjee S, Ray D, Raha S. Involvement of the Akt/PKB signaling pathway with disease processes. Mol Cell Biochem 2003; 253: 241–6.

 
Datta, D., Banerjee, S., Ghosh, A., Mustafi, S. B., Sen, P. & Raha, S. Involvement of Heat Shock Protein 70 (HSP70) in Gastrointestinal Cancers in Human Diseases and Disorders 71–91 (Springer Nature, 2018). doi: 10.1007/978-3-319-89551-2_4
 
Prasad, R., Roy, A. & Sen, P. Functional Aspects of Activated Protein C (APC) in Regulating Homeostasis and Disease in Proteases in Human Diseases 395–408 (Springer Nature Singapore, 2017). doi:10.1007/978-981-10-3162-5_18
 
Roy, A., Prasad, R., Bhattacharya, A., Das, K. & Sen, P. Role of Tissue Factor-FVIIa Blood Coagulation Initiation Complex in Cancer in Proteases in Physiology and Pathology 101–119 (Springer Nature Singapore, 2017). doi:10.1007/978-981-10-2513-6_6

 


Teaching



Open Positions

Position Available

Candidates with DST-INSPIRE, CSIR or UGC-JRF, DBT-JRF qualifications having strong motivation for research and good academic background in Organic Chemistry, Bioinformatics or Life Sciences are encouraged to apply for PhD.

 


Department


Project Students Alumni

List of Summer Trainees coming from various Universities/Institutes:

1. Mr. Arnab Das (Hooghly Mohsin College, Burdwan University)

2. Mr. Ratan Lagdi (Narendrapur, Ramakrishna Mission College)

3. Mr. Himadri Sekhar Sasmal (IIT, KGP)

4. Ms. Ankita Bal (Barrackpore Rastra Guru Surendranath College)

5. Ms. Piyali Adhikary (Calcutta University)

6. Ms. Ankita Das (Calcutta University)

7. Mr. Purnam Ghosh (St. Xavier's College, Kolkata)

8. Mr. Prasoon Madhukar (BHU)

9. Mr. Ashutosh Sahu (NIT, Rourkela)

10. Ms. Arundathi Medya (Jadavpur University)

11. Mr. Krishnendu Maji (Kalyani University)

12. Mr. Nayan Chakraborty (Belur Math, Ramakrishna Mission College)

13. Ms. Shreyoshi Chakraborty (Calcutta University)

14. Ms. Anumita Dey (Vidyasagar University)

15. Mr. Niladri Goswami (WBUT)

16. Mr. Soumayan Sarkar (Calcutta University)

17. Ms. Sreetama Roy (Calcutta University)

18. Mr. Soumik Kundu (Jadavpur University)

19. Mr. Arnab Ghosh (Calcutta University)

20. Ms. Anwesha Mukherjee (Calcutta University)

21. Ms. Sunanda Ghosh (Kalyani University)

22. Ms. Debopriya Goon (IIT Kharagpur)


Honors/Awards



Alumni

Dr. Abhishek Roy

Current Position - Post Doctoral Fellow at Virginia Commonwealth University (VCU), Virginia, USA.

 

Dr. Ramesh Prasad

Current Position - Post Doctoral Fellow at University of Illinois, Chicago, USA.

 

Dr. Kaushik Das

Current Position - Post Doctoral Fellow at University of Texas Health Science Center at Tyler, Texas, USA.

 

Dr. Shabbir Ansari

Current Position - Post Doctoral Fellow at Harvard Medical School, USA.

 

Dr. Ruma Sarkar

Current Position - Assistant Professor, ICFAI University, Tripura.