Supramolecular self-assemblies: Biocatalysis to Biomedicine
Our research objective involves designing of task specific functional amphiphiles, gels, vesicles, carbon nanomaterial (CNT, GO, CNP) doped soft nanocomposites, metal nanoparticle doped self-assemblies and other self-assemblies. These self-assemblies are employed in versatile disciplines of science from biocatalysis to biomedicinal applications that includes intracellular cargo (drug/DNA/protein) delivery, biosensing, antimicrobial tissue engineering scaffolds. We are also in a constant endeavor to improve the catalytic efficiency of enzyme confined in aggregated structure through modulation of space in vicinity of biocatalysts.
SPECIFIC AIM & CURRENT RESEARCH INTERESTS
PUBLICATION
Number of Peer Reviewed Publications: 140
Book Chapter: 3
Patents: 5 US patents and 2 Indian Patents
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Number Students received/submitted thesis for ph.d. degree: 22
Number of Ongoing ph.d. students: 7
Publications |
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List of Publications
Book Chapter:
1. Tanmoy Kar and Prasanta Kumar Das*. ‘Molecular Gels as Templates for Nanostructured Materials’, Book entitled “Functional Molecular Gels”. Edited by Beatriu Escuder and Juan F. Miravet; The Royal Society of Chemistry 2013, Vol. 1, pp 255-303.
2. Prasanta Kumar Das*. “History of Carbon Nanomaterials”: ‘History of Science in India: Chemical Science’; The National Academy of Sciences, India; The Ramakrishna Mission Institute of Culture, 2014 Vol III, pp 150-155. 3. Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and Arabinda Chaudhuri. ‘Novel cationic transfection lipids for use in liposomal gene delivery’, Book entitled “Adsorption and Aggregation of Surfactants in Solution” edited by K. L. Mittal. Dinesh O. Shah; Marcel Dekker, Inc. New York 2003, Surfactant Science Series Vol. 109, pp 603-617.
Peer Reviewed articles:
140. Afreen Zaman, Aparajita Ghosh, Anup Kumar Ghosh and Prasanta Kumar Das*. DON encapsulated carbon dot-vesicle conjugate in therapeutic intervention of lung adenocarcinoma by dual targeting of CD44 and SLC1A5. Nanoscale, 2024, DOI: 10.1039/D4NR00426D
139. Aftab Hossain Khan, Ambalika Basak, Afreen Zaman and Prasanta Kumar Das*. Inherently targeted estradiol-derived carbon dots for selective killing of ER (+) breast cancer cells via oridonin-triggered p53 pathway activation. Journal of Materials Chemistry B 2024, 12, 11708-11720, DOI: 10.1039/D4TB01415D.
138. Sudeshna Pal, Rajarshi Mondal and Prasanta Kumar Das*. Nanogel-Carbon Dot Conjugates: A Synergistic Approach for Enhanced Cancer Treatment through Combination Therapy. ACS Med. Chem. Lett., 2024, 15, 1668–1676
137. Monalisa Chowdhury, Debolina Basu and Prasanta Kumar Das*.Cu2+-integrated carbon dots as an efficient bioprobe for the selective sensing of guanine nucleobase. Sens. Diagn., 2024, 3, 1329–1343.
136. Dibakar Sarkar, Aftab Hossain Khan, Sainath Polepalli, Riddhiman Sarkar, Prasanta Kumar Das, Somnath Dutta,* Nirakar Sahoo,* and Anirban Bhunia*. Multiscale Materials Engineering via Self-Assembly of Pentapeptide Derivatives from SARS CoV E Protein. Small 2024, 2404373.
135. Anup Kumar Ghosh, Kathakoli Roy and Prasanta Kumar Das*. Organic Nanoparticle-Carbon dots Conjugate for Multimodal Cancer Therapy. ACS Applied Nano Materials 2024, 7, 4946-4959.
134. Anup Kumar Ghosh, Aparajita Ghosh, and Prasanta Kumar Das*. Nanotechnology Meets Stem Cell Therapy for Treating Glioblastomas: A Review. ACS Applied Nano Materials 2024 7, 2430-2460. (Invited Review Article)
133. Monalisa Chowdhury and Prasanta Kumar Das*. Hypoxia: Intriguing Feature in Cancer Cell Biology. ChemMedChem 2024, e202300551. (Invited Review Article)
132. Kathakoli Roy, Anup Kumar Ghosh and Prasanta Kumar Das*. Naphthalene Diimide based Orange Emitting Luminogen: A Fluorometric Probe for Thiol Sensing through Click Reaction. Langmuir 2023, 39, 44, 15690–15704. https://doi.org/10.1021/acs.langmuir.3c02221.
131. Aparajita Ghosh, Anup Kumar Ghosh, Afreen Zaman and Prasanta Kumar Das*. Metformin Loaded Hyaluronic Acid Derived Carbon Dots for Targeted Therapy against Hepatocellular Carcinoma by Glutamine Metabolic Reprogramming. Molecular Pharmaceutics 2023, https://doi.org/10.1021/acs.molpharmaceut.3c00772.
130. Anup Kumar Ghosh, Aftab Hossain Khan and and Prasanta Kumar Das*. Naphthalimide based AIEgens for Sensing Protein Disulfide Isomerase through Thiol-Disulfide Redox Exchange. Anal. Chem. 2023, 95, doi.org/10.1021/acs.analchem.3c02442
129. Monalisa Chowdhury, Sudeshna Pal, Aprajita Ghosh and Prasanta Kumar Das*. Co2+ Doped Biotinylated Carbon Dot: A Theranostic Agent for Target Specific Killing of Cancer Cells via Hypoxia Induced Apoptosis. Chem. Eur. J. 2023, 29, e202300928.
128. Sudeshna Pal,# Madhurima Jana,# Monalisa Chowdhury and Prasanta Kumar Das* (# Authors contributed equally). Selective Sensing of Epinephrine by Phenylboronic Acid Tethered Carbon Dot. Chem. Asian J. 2023, 18, http://dx.doi.org/10.1002/asia.202300415.
127. Sudeshna Pal, Aftab Hossain Khan, Monalisa Chowdhury and Prasanta Kumar Das*. Peptide Amphiphilic Supramolecular Nanogel: Competent Host for Notably Efficient Lipase Catalyzed Hydrolysis of Water Insoluble Substrates. ChemBioChem 2023, 24, e202300253.
126. Aftab Hossain Khan, Sudeshna Pal, Anup Kumar Ghosh and Prasanta Kumar Das*. Amino Acid and Dipeptide Amphiphile Based Supramolecular Eutectogels: Soft Materials for Drug Entrapment-Release and Waste-Water Treatment. ACS Applied Engineering Materials 2023, 1, 1809-1821.
125. Deblina Sarkar, Anup Kumar Ghosh, Aftab Hossain Khan and Prasanta Kumar Das*. Organic nanoparticles with tunable AIE derived from amino acids appended naphthalenediimide based amphiphiles. Journal of Molecular Liquids, 2023, 382, 121824.
124. Deblina Sarkar, Monalisa Chowdhury and Prasanta Kumar Das*. Naphthalimide Based Azo Functionalized Supramolecular Vesicle in Hypoxia-Responsive Drug Delivery. Langmuir 2022, 38, 3480-3492.
123. Aparajita Ghosh, Anup Kumar Ghosh, Monalisa Chowdhury and and Prasanta Kumar Das*. Folic Acid Functionalized Carbon Dot Enabled Starvation Therapy in Synergism with Paclitaxel Against Breast Cancer. ACS Applied Bio Materials 2022, 5, 2389-2402.
122. Anup Kumar Ghosh, Monalisa Chowdhury and Prasanta Kumar Das*. Nipecotic Acid Tethered Naphthalene Diimide based Orange Emitting Organic Nanoparticles as Targeted Delivery Vehicle and Diagnostic Probe towards GABAA Receptor Enriched Cancer Cells. ACS Applied Bio Materials 2021, 4, 7563−7577.
121. Monalisa Chowdhury and Prasanta Kumar Das*. Paclitaxel Loaded Biotinylated Fe2+ Doped Carbon Dot: Combination Therapy in Cancer Treatment. ACS Applied Bio Materials 2021, 4, 5132−5144.
120. Deblina Sarkar, Monalisa Chowdhury and Prasanta Kumar Das*. Naphthalimide based fluorescent organic nanoparticle in selective sensing of Fe3+ and as diagnostic probe for Fe2+/Fe3+ transition. Journal of Materials Chemistry B 2021, 9, 494 - 507.
119. Debayan Chakraborty, Deblina Sarkar, Anup Kumar Ghosh and Prasanta Kumar Das*. Lipase sensing by naphthalene diimide based fluorescent organic nanoparticles: a solvent induced manifestation of self-assembly. Soft Matter 2021, 17, 2170-2180.
118. Pritam Choudhury, and Prasanta Kumar Das*. Progress and Trends in Self-Assembly Driven Fluorescent Organic Nanoparticles: A Brief Overview. Journal of the Indian Chemical Society (Invited Review Article), 2021, 98, 100123. 117. Pritam Choudhury, Soumik Dinda and Prasanta Kumar Das*.Fabrication of soft-nanocomposites from functional molecules with diversified applications. Soft Matter 2020, 16. 27-53.
116. Anup Kumar Ghosh, Pritam Choudhury and Prasanta Kumar Das*. Fabrication of Orange Emitting Organic Nanoparticle-Protamine Conjugate: Fluorimetric Sensor of Heparin. Langmuir, 2019, 35, 15180-15191.
115. Pritam Choudhury and Prasanta Kumar Das*. Carbon Dots Stimulated Amplification of Aggregation Induced Emission of Size Tunable Organic Nanoparticles. Langmuir, 2019, 35, 10582-10595.
114. Monalisa Chowdhury, Saheli Sarkar and Prasanta Kumar Das*. Photosensitizer Tailored Surface Functionalized Carbon Dots for Visible Light Induced Targeted Cancer Therapy. ACS Applied Bio Materials 2019, 2, 4953-4965.
113. Soumik Dinda and Prasanta Kumar Das*. Metal Ion (Fe2+ and Co2+) Induced Morphological Transformation of Self-Aggregates of Cholesterol Tethered Bipyridine Amphiphile: Selective Cancer Cell Killing by Pro-Drug Activation. ACS Applied Bio Materials 2019, 2, 3737-3747. 112. Saheli Sarkar, Soumik Dinda, Pritam Choudhury and Prasanta Kumar Das*. Self-assembly of surface functionalized amphiphilic carbon dots: tuning in the morphological manifestation. Soft Matter 2019, 15, 2863-2875.
111. Debayan Chakraborty, Soumik Dinda, Monalisa Chowdhury and Prasanta Kumar Das*. Morphological transformation of self-assemblies by tuning hydrophobic segment of small amphiphiles. J. Colloid Interface Sci. 2019, 539, 414-424.
110. Samapti Kundu, Sumanta Sain, Pritam Choudhury, Saheli Sarkar, Prasanta Kumar Das, Swapan Kumar Pradhan. Microstructure characterization of biocompatible heterojunction hydrogen titanate-Ag2O nanocomposites for superior visible light photocatalysis and antibacterial activity. Materials Science & Engineering C, 2019, 99, 374-386.
109. Pritam Choudhury, Saheli Sarkar and Prasanta Kumar Das*. Tunable Aggregation Induced Multicolour Emission of Organic Nanoparticles by Varying Substituent in Naphthalene Diimide. Langmuir, 2018, 34, 14328-14341
108. Soumik Dinda, Saheli Sarkar and Prasanta Kumar Das*. Glucose Oxidase Mediated Targeted Cancer-Starving Therapy by Biotinylated Self-Assembled Vesicle. Chem. Commun. 2018, 54, 9929-9932.
107. Saheli Sarkar, Pritam Choudhury, Soumik Dinda and Prasanta Kumar Das*. Tailor-Made Self-Assemblies from Functionalized Amphiphiles: Diversity and Applications. Langmuir 2018, 34, 10449-10468. (Invited Feature Article, Selected as ACS Editor's Choice).
106. Deblina Sarkar, Pritam Choudhury, Soumik Dinda and Prasanta Kumar Das*. Vesicle Formation by Cholesterol based Hydrazone Tethered Amphiphiles: Stimuli Responsive Dissipation of Self-Assembly. J. Colloid Interface Sci. 2018, 530, 67-77.
105. Debayan Chakraborty, Saheli Sarkar, and Prasanta Kumar Das*. Blood Dots: Hemoglobin-Derived Carbon Dots as Hydrogen Peroxide Sensors and Pro-Drug Activators. ACS Sustainable Chemistry & Engineering, 2018, 6, 4661-4670.
104. Soumik Dinda, Deep Mandal, Saheli Sarkar and Prasanta Kumar Das*. Self-Assembled Vesicle-Carbon Nanotube Conjugate Formation through Boronate-Diol Covalent Linkage. Chem. Eur. J. 2017, 23, 15194-15202.
103. Deep Mandal, Pritam Choudhury, Deblina Sarkar and Prasanta Kumar Das*. Dissipation of Self-assemblies by Fusion of Complementary Gels: An Elegant Strategy for Programmed Enzymatic Reaction. Chem. Commun. 2017, 53, 7844-7847.
102. Saheli Sarkar, Krishnendu Das and Prasanta Kumar Das*. Estradiol Hemisuccinate Modified Surface Engineered Carbon Dots: Target Specific Theranostic Agent. ACS Sustainable Chemistry & Engineering, 2017, 5, 8356-8369.
101. Pritam Choudhury, Krishnendu Das and Prasanta Kumar Das*. L-Phenylalanine Tethered Naphthalene Diimide Based Aggregation Induced Green Emitting Organic Nanoparticles. Langmuir 2017, 33, 4500-4510.
100. Krishnendu Das, Sahithi Nimushakavi, Arabinda Chaudhuri and Prasanta Kumar Das*. Integrin Receptor Targeting RGDK Tagged Nanocarrier: Anticancer Efficacy of Loaded Curcumin. ChemMedChem 2017, 12, 738-750.
99. Krishnendu Das, Saheli Sarkar and Prasanta Kumar Das*. Fluorescent Indicator Displacement Assay: Ultrasensitive Detection of Glutathione and Selective Cancer Cell Imaging. ACS Appl. Mater. Interfaces 2016, 8, 25691−25701.
98. Deep Mandal, Soumik Dinda, Pritam Choudhury and Prasanta Kumar Das*. Solvent Induced Morphological Evolution of Cholesterol Based Glucose Tailored Amphiphiles: Transformation from Vesicles to Nanoribbons. Langmuir 2016, 32, 9780−9789.
97. Soumik Dinda, Moumita Ghosh and Prasanta Kumar Das*. Spontaneous Formation of Vesicular Assembly by Trimesic Acid Based Triple Tailed Amphiphile. Langmuir 2016, 32, 6701-6712.
96. Saheli Sarkar, Krishnendu Das and Prasanta Kumar Das*. Hydrophobically Tailored Carbon Dots towards Modulating Microstructure of Reverse Micelle and Amplification of Lipase Catalytic Response. Langmuir 2016, 32, 3890-3900.
95. Pritam Choudhury, Deep Mandal, Sayanti Brahmachari and Prasanta Kumar Das*. Hydrophobic End Modulated Amino Acid Based Neutral Hydrogelators: Structure Specific Inclusion of Carbon Nanomaterials. Chem. Eur. J. 2016, 22, 5160-5172 (considered as ‘HOT’ paper).
94. Moumita Ghosh, and Prasanta Kumar Das*. Doxorubicin loaded 17β-estradiol based SWNT dispersions for target specific killing of cancer cells. Colloid Surface B: Biointerfaces 2016, 142, 367-376.
93. Subhra Kanti Mandal, Deep Mandal and Prasanta Kumar Das*. Synthesis of Low-Molecular-Weight Fluorescent Ambidextrous Gelator: Development of Graphene and Graphene Oxide Included Gel-Nanocomposite. ChemPlusChem 2016, 81, 213-221.
92. Sushovan Lala, Moumita Ghosh, Prasanta Kumar Das, D. Das, Tanushree Kar, and Swapan Kumar Pradhan. Magnesium substitution in carbonated hydroxyapatite: Structural and microstructural characterization by Rietveld's refinement. Mat. Chem. Phys. 2016, 170, 319-329.
91. Deep Mandal, Subhra Kanti Mandal, Moumita Ghosh and Prasanta Kumar Das*. Phenylboronic Acid Appended Pyrene Based Low Molecular Weight Injectable Hydrogel: Glucose Stimulated Insulin Release. Chem. Eur. J. 2015, 21, 12042-12052. (considered as ‘HOT’ paper). Highlighted in ChemistryViews Magazine: http://www.chemistryviews.org/details/ezine/8119491/Sweet_Gels_for_Diabetics.html
90. Saheli Sarkar, Krishnendu Das, Moumita Ghosh, and Prasanta Kumar Das*. Amino acid functionalized blue and phosphorous-doped green fluorescent carbon dots as bioimaging probe. RSC Adv. 2015, 5, 65913-65921.
89 Sushovan Lala, Moumita Ghosh, Prasanta Kumar Das, Tanushree Kar , Swapan Kumar Pradhan. Mechanical preparation of nanocrystalline biocompatible single phase Mn doped A-type carbonated hydroxyapatite (A-cHAp): Effect of Mn doping on microstructure. Dalton Transactions 2015, 44, 20087-20097.
88. Sushovan Lala, Moumita Ghosh, Prasanta Kumar Das, D. Das, Tanushree Kar , Swapan Kumar Pradhan. Structural and microstructural interpretations of Zn-doped biocompatible bone like carbonated hydroxyapatite synthesized by mechanical alloying. Journal of Applied Crystallography, 2015, 48, 138-148.
87. Deep Mandal, Tanmoy Kar and Prasanta Kumar Das*. Pyrene Based Fluorescent Ambidextrous Gelator: Scaffold for Mechanically Robust SWNT-Gel Nanocomposite. Chem. Eur. J. 2014, 20, 1349-1358.
86. Krishnendu Das, Subhabrata Maiti, and Prasanta Kumar Das*. Probing Enzyme Location in Water-in-Oil Microemulsion Using Enzyme-Carbon Dot Conjugates. Langmuir 2014, 30, 2448-2459.
85. Sayanti Brahmachari, Subhra Kanti Mandal, and Prasanta Kumar Das*. Fabrication of SWCNT-Ag Nanoparticle Hybrid Included Self-Assemblies for Antibacterial Applications. PLOS ONE 2014, 9, e106775.
84. Subhra Kanti Mandal, Sayanti Brahmachari and Prasanta Kumar Das*. In Situ Synthesized Ag Nanoparticle Infused L-Lysine Based Injectable Hydrogel: Development of Biocompatible Antibacterial Soft-Nanocomposite. ChemPlusChem 2014, 79, 1733-1746.
83. Moumita Ghosh, Sayanti Brahmachari and Prasanta Kumar Das*. pH-Responsive Single Walled Carbon Nanotube Dispersion for Target Specific Release of Doxorubicin to Cancer Cells. Macromol. Biosci. 2014, 14, 1795-1806.
82. Subrata Mukherjee, Tanmoy Kar and Prasanta Kumar Das*. Pyrene Based Fluorescent Supramolecular Hydrogel: Scaffold for Energy Transfer. Chem. Asian J. 2014, 9, 2798-2805.
81. Sayanti Brahmachari, Moumita Ghosh, Sounak Dutta, and Prasanta Kumar Das*. Biotinylated amphiphile-single walled carbon nanotube conjugate for target-specific delivery to cancer cells. J. Mater. Chem. B 2014, 2, 1160-1173.
80. Animesh Pan, Pallabi Sil, Sounak Dutta, Prasanta Kumar Das, Subhash C Bhattacharya, Animesh K Rakshit, Vinod K Aswal, Satya P Moulik. Micellization of Cetyltrimethylammonium Bromide: Effect of Small Chain Bola Electrolytes. J. Phys. Chem. B 2014, 118, 3041-3052.
79. Tanmoy Kar, Subrata Mukherjee and Prasanta Kumar Das*. Organogelation Through Self-Assembly of Low-Molecular-Mass Amphiphilic Peptide. New Journal of Chemistry 2014, 38, 1158-1167.
78. Deep Mandal, Moumita Ghosh, Subhabrata Maiti, Krishnendu Das and Prasanta Kumar Das*.Water-in-oil microemulsion doped with gold nanoparticle decorated single walled carbon nanotube: scaffold for enhancing lipase activity. Colloid Surface B: Biointerfaces 2014, 113, 442-449.
77. Sushovan Lala, Sayanti Brahmachari, Prasanta Kumar Das, D. Das, Tanushree Kar , Swapan Kumar Pradhan Biocompatible nanocrystalline natural bonelike carbonated hydroxyapatite synthesized by mechanical alloying in a record minimum time. Materials Science and Engineering C, 2014, 42, 647-656.
76. Prasanta Kumar Das*. Self-Assembled Supramolecular Materials: Prospects in Biocatalysis to Biomedicine. SMC Bulletin 2014, 5, 31-34.
75. Subhabrata Maiti, Krishnendu Das and Prasanta Kumar Das*. Label-Free Fluorimetric Detection of Histone Using Quaternized Carbon Dot-DNA Nanobiohybrid. Chem. Commun. 2013, 49, 8851-8853.
74. Subhra Kanti Mandal, Tanmoy Kar, and Prasanta Kumar Das*. Pristine Carbon Nanotube Included Supramolecular Hydrogel with Tunable Viscoelastic Properties. Chem. Eur. J. 2013, 19, 12486-12496.
73. Sounak Dutta, Tanmoy Kar, Deep Mandal and Prasanta Kumar Das*. Structure and Properties of Cholesterol Based Hydrogelators with Varying Hydrophilic Terminals: Biocompatibility and Development of Antibacterial Soft Nanocomposites. Langmuir 2013, 29, 316-327.
72. Krishnendu Das, Subhabrata Maiti, Moumita Ghosh, Deep Mandal and Prasanta Kumar Das*. Graphene Oxide in CTAB Reverse Micelle: A Befitting Soft Nanocomposite for Improving Efficiency of Surface-Active Enzymes. J. Colloid Interface Sci. 2013, 395, 111-118.
71. Tanmoy Kar, Subhra Kanti Mandal and Prasanta Kumar Das*. Influence of pristine SWNT in supramolecular hydrogelation: scaffold for superior peroxidase activity of cytochrome c. Chem. Commun. 2012, 48, 8389-8391.
70. Subhra Kanti Mandal, Tanmoy Kar, Dibyendu Das and Prasanta Kumar Das*. The Striking influence of SWNT-COOH on self-assembled gelation. Chem. Commun. 2012, 48, 1814-1816.
69. Subhabrata Maiti, Krishnendu Das, Sounak Dutta and Prasanta Kumar Das*. Striking Improvement in Peroxidase Activity of Cytochrome C by Modulating Hydrophobicity of Surface-Functionalized GNPs within Cationic Reverse Micelle. Chem. Eur. J. 2012, 18, 15021-15030.
68. Sounak Dutta, Tanmoy Kar, Sayanti Brahmachari and Prasanta Kumar Das*. pH-responsive reversible dispersion of biocompatible SWNT/Graphene-amphiphile hybrids. J. Mater. Chem. 2012, 22, 6623-6631.
67. Dibyendu Das, Tanmoy Kar and Prasanta Kumar Das*. Gel-Nanocomposites: Materials with Promising Applications. Soft Matter 2012, 8, 2348-2365. (Invited Review Article)
66. Moumita Ghosh, Subhabrata Maiti, Sounak Dutta, Dibyendu Das and Prasanta Kumar Das*. Covalently Functionalized SWNT at Reverse Micellar Interface: A Strategy to Improve Lipase Activity. Langmuir 2012, 28, 1715-1724.
65. Moumita Ghosh, Subhabrata Maiti, Sayanti Brahmachari and Prasanta Kumar Das*. GNP Confinement at the Interface of Cationic Reverse Micelle: Influence in Improving the Lipase Activity. RSC Adv. 2012, 2, 9042-9051.
64. Deenan Santhiya, Rita S. Dias,* Sounak Dutta, Prasanta Kumar Das*, Maria G. Miguel, Björn Lindman and Souvik Maiti*. Kinetic Studies of Amino Acid Based Surfactant Binding to DNA. J. Phys. Chem. B 2012, 116, 5831-5837.
63. Sayanti Brahmachari, Dibyendu Das, Anshupriya Shome and Prasanta Kumar Das*. Single-Walled Nanotube/Amphiphile Hybrids for Efficacious Protein Delivery: Rational Modification of Dispersing Agents Angew. Chem. Int. Ed. 2011, 50, 11243-11247.
62. Subhabrata Maiti, Moumita Ghosh and Prasanta Kumar Das*. Gold Nanorod in Reverse Micelles: A Fitting Fusion to Catapult Lipase Activity. Chem. Commun. 2011, 47, 9864-9866.
61. Tanmoy Kar, Subhra Kanti Mandal and Prasanta Kumar Das*. Organogel-Hydrogel Transformation by Simple Removal and Inclusion of Boc-Protection. Chem. Eur. J. 2011, 17, 14952-14961.
60. Subhabrata Maiti, Sounak Dutta and Prasanta Kumar Das*. Unmodified ‘GNP-Oligonucleotide’ Nano-biohybrids: Simple Route for Emission Enhancement of DNA Intercalators. Chem. Eur. J. 2011, 17, 7538-7548.
59. Dibyendu Das, Subhabrata Maiti, Sayanti Brahmachari and Prasanta Kumar Das*. Refining Hydrogelator Design: Soft Materials with Improved Gelation Ability, Biocompatibility and Matrix for in situ Synthesis of Specific Shaped GNP. Soft Matter 2011, 7, 7291-7303.
58. Anshupriya Shome, Sounak Dutta, Subhabrata Maiti and Prasanta Kumar Das*. In situ synthesized Ag nanoparticle in self-assemblies of amino acid based amphiphilic hydrogelators: development of antibacterial soft nanocomposites. Soft Matter 2011, 7, 3011-3022.
57. Sounak Dutta, Anshupriya Shome, Tanmoy Kar and Prasanta Kumar Das*. Counterion-Induced Modulation in the Antimicrobial Activity and Biocompatibility of Amphiphilic Hydrogelators: Influence of in situ Synthesized Ag-nanoparticle on the Bactericidal Property. Langmuir 2011, 27, 5000-5008.
56. Anshupriya Shome, Tanmoy Kar, and Prasanta Kumar Das*. Spontaneous Formation of Biocompatible Vesicles in Aqueous Mixtures of Amino Acid-Based Cationic Surfactants and SDS/SDBS. ChemPhysChem, 2011, 11, 369-378.
55. Pranabesh Dutta, Joykrishna Dey*, Anshupriya Shome, Prasanta Kumar Das*. Nanostructure formation in aqueous solution of amphiphilic copolymers of 2-(N,N-dimethylaminoethyl)methacrylate and alkylacrylate: Characterization, antimicrobial activity, DNA binding, and cytotoxicity studies. International Journal of Pharmaceutics 2011, 414, 298-311.
54. Sayanti Brahmachari, Dibyendu Das and Prasanta Kumar Das*. Superior SWNT dispersion by amino acid based amphiphiles: designing biocompatible cationic nanohybrids. Chem. Commun. 2010, 46, 8386-8388.
53. Dibyendu Das, Sangita Roy, Sisir Debnath and Prasanta Kumar Das*. Surfactant Stabilized Small Hydrogel Particles in Oil: Hosts for Remarkable Activation of Enzymes in Organic Solvents. Chem. Eur. J. 2010, 16, 4911-4922.
52. Subhabrata Maiti, Dibyendu Das, Anshupriya Shome and Prasanta Kumar Das*. Influence of Varying Sized Gold Nanoparticles in Improving the Lipase Activity within Cationic Reverse Micelles. Chem. Eur. J. 2010, 16, 1941-1950.
51. Sounak Dutta, Dibyendu Das, Antara Dasgupta and Prasanta Kumar Das*. Amino Acid-Based Low-Molecular-Weight Ionogels as Efficient Dye-Adsorbing Agents and Template for the Synthesis of TiO2 Nanoparticles. Chem. Eur. J. 2010, 16, 1493-1505.
50. Tanmoy Kar, Sounak Dutta, and Prasanta Kumar Das*. pH-Triggered conversion of soft nanocomposites: in situ synthesized AuNP-hydrogel to AuNP-organogel. Soft Matter 2010, 6, 4777-4787.
49. Sisir Debnath, Dibyendu Das, Sounak Dutta and Prasanta Kumar Das*. Imidazolium Bromide-Based Ionic Liquid Assisted Improved Activity of Trypsin in Cationic Reverse Micelles. Langmuir 2010, 26, 4080-4086.
48. Sisir Debnath, Anshupriya Shome, Dibyendu Das and Prasanta Kumar Das*. Hydrogelation Through Self-Assembly of Fmoc-Peptide Functionalized Cationic Amphiphiles: Potent Antibacterial Agent. J. Phys. Chem. B 2010, 114, 4407-4415.
47. Kajari Maiti, Debolina Mitra, Rajendra Narayan Mitra, Amiya K. Panda, Prasanta Kumar Das, Animesh K. Rakshit and Satya P. Moulik. Self-Aggregation of Synthesized Novel Bolaforms and their Mixtures with Sodium Dodecylsulfate (SDS) and Cetyltrimethylammonium Bromide (CTAB) in Aqueous Medium. J. Phys. Chem. B 2010, 114, 7499-7508.
46. Sayanti Brahmachari, Sisir Debnath, Sounak Dutta, and Prasanta Kumar Das*. Pyridinium based amphiphilic hydrogelators as potential antibacterial agents. Beilstein Journal of Organic Chemistry 2010, 6, 859-868 (Thematic series on “Organic Gelators and Hydrogelators”, Invited Article).
45. Sounak Dutta, Anshupriya Shome, Sisir Debnath, and Prasanta Kumar Das*. Counterion dependent hydrogelation of amino acid-based amphiphiles: switching from non-gelators to gelators and facile synthesis of silver nanoparticles. Soft Matter 2009, 5, 1607-1620.
44. Dibyendu Das and Prasanta Kumar Das*. Superior Activity of Structurally Deprived Enzyme-Carbon Nanotube Hybrids in Cationic Reverse Micelles. Langmuir 2009, 25, 4421-4428.
43. Tanmoy Kar, Sisir Debnath, Dibyendu Das, Anshupriya Shome, and Prasanta Kumar Das*. Organogelation and Hydrogelation of Low-Molecular-Weight Amphiphilic Dipeptides: pH-Responsiveness in Phase Selective Gelation and Dye Removal. Langmuir 2009, 25, 8639-8648.
42. Deenan Santhiya, Rita S. Dias,* Anshupriya Shome, Prasanta Kumar Das*, Maria G. Miguel, Björn Lindman and Souvik Maiti1*. Role of linker groups between hydrophilic and hydrophobic moieties of cationic surfactants on the oligonucleotide – surfactant interactions. Langmuir 2009, 25, 13770-13775.
41. Rajendra Narayan Mitra, Anshupriya Shome, Pritha Paul, and Prasanta Kumar Das*. Antimicrobial activity, biocompatibility and hydrogelation ability of dipeptide-based amphiphiles. Org. Biomol. Chem. 2009, 7, 94-102.
40. Sisir Debnath, Anshupriya Shome, Sounak Dutta, and Prasanta Kumar Das*. Dipeptide Based Low-Molecular-Weight Efficient Organogelators and Its Application in Water Purification. Chem. Eur. J. 2008, 14, 6870-6881(in the Cover Page).
39. Anshupriya Shome, Sisir Debnath, and Prasanta Kumar Das*. Head Group Modulated pH-Responsive Hydrogel of Amino Acid- Based Amphiphiles: Entrapment and Release of Cytochrome c and Vitamin B12. Langmuir 2008, 24, 4280-4288.
38. Rajendra Narayan Mitra, and Prasanta Kumar Das*. In situ Preparation of Gold Nanoparticles of Varying Shape in Molecular Hydrogel of Peptide Amphiphiles. J. Phys. Chem. C 2008, 112, 8159-8166.
37. Rita S. Dias,* Luís M. Magno, Artur J. M. Valente, Dibyendu Das, Prasanta Kumar Das*, Souvik Maiti,* Maria G. Miguel, and Björn Lindman. Interaction between DNA and Cationic Surfactants: Effect of DNA Conformation and Surfactant Headgroup. J. Phys. Chem. B 2008, 112, 14446-14452.
36. Vaibhav M. Jadhav, Souvik Maiti*, Antara Dasgupta, Prasanta Kumar Das*, Rita S. Dias*, Maria G. Miguel, Björn Lindman. Effect of the head-group geometry of amino-acid based cationic surfactants on interaction with plasmid DNA. Biomacromolecules 2008, 9, 1852-1859.
35. Sangita Roy, and Prasanta Kumar Das*. Antibacterial Hydrogels of Amino Acid-Based Cationic Amphiphiles. Biotechnology and Bioengineering 2008, 100, 756-764.
34. Dibyendu Das, Debapratim Das, Prasanta Kumar Das*. Improved activity of enzymes in mixed cationic reverse micelles with imidazolium-based surfactants. Biochimie 2008, 90, 820-829.
33. Nilanjan Kayal, Sangita Roy, Rajendra Narayan Mitra and Prasanta Kumar Das*. Antimicrobial Activity of Amino Acid and Dipeptide Based Amphiphiles. Journal of Biotechnology 2008, 136, S28-S29.
32. Rajendra Narayan Mitra, Debapratim Das, Sangita Roy, and Prasanta Kumar Das*. Structure and Properties of Low Molecular Weight Amphiphilic Peptide Hydrogelators. J. Phys. Chem. B 2007, 111, 14107-14113.
31. Antara Dasgupta, Prasanta Kumar Das*, Rita S. Dias*, Maria G. Miguel, Björn Lindman, Vaibhav M. Jadhav, Muthaiah Gnanamani, Souvik Maiti*. Effect of headgroup on DNA-cationic surfactant interactions J. Phys. Chem. B 2007, 111, 8502-8508.
30. Sangita Roy, Antara Dasgupta, and Prasanta Kumar Das*. Alkyl Chain Length Dependent Hydrogelation of L-Tryptophan Based Amphiphile. Langmuir 2007, 23, 11769-11776.
29. Antara Dasgupta, Debapratim Das, and Prasanta Kumar Das*. Probing the Relationship Between Interfacial Concentrations and Lipase Activity in Cationic W/O Microemulsions: A Quantitative Study by Chemical Trapping. Langmuir 2007, 23, 4137-4143 (back-to-back).
28. Anshupriya Shome, Sangita Roy, and Prasanta Kumar Das* Nonionic Surfactants: A Key to Enhance the Enzyme Activity at Cationic Reverse Micellar Interface. Langmuir 2007, 23, 4130-4136 (back-to-back).
27. Sisir Debnath, Dibyendu Das, and Prasanta Kumar Das* Unsaturation at the surfactant head: Influence on the activity of lipase and horseradish peroxdiase in reverse micelles. Biochemical and Biophysical Research Communications 2007, 356, 163-168.
26. Dibyendu Das, Antara Dasgupta and Prasanta Kumar Das* Improved activity of horseradish peroxidase (HRP) in ‘specifically designed’ ionic liquid. Tetrahedron Lett. 2007, 48, 5635-5639.
25. Debapratim Das, Antara Dasgupta, Sangita Roy, Rajendra Narayan Mitra, Sisir Debnath, and Prasanta Kumar Das*. Water Gelation of an Amino Acid Based Amphiphile. Chem. Eur. J. 2006, 12, 5068-5074 (in the Cover Page).
24. Sisir Debnath, Antara Dasgupta, Rajendra Narayan Mitra, and Prasanta Kumar Das*. Effect of Counterions on the Activity of Lipase in Cationic Water-in-Oil Microemulsions. Langmuir 2006, 22, 8732-8740.
23. Sangita Roy, Antara Dasgupta, and Prasanta Kumar Das*. Tailoring of Horseradish Peroxidase Activity in Cationic Water-in-Oil Microemulsions. Langmuir 2006, 22, 4567-4573.
22. Debolina Mitra, Indranil Chakraborty, Subhash C. Bhattacharya, Satya P. Moulik*, Sangita Roy, Debapratim Das, and Prasanta Kumar Das*. Physicochemical studies on cetylammonium bromide and its modified (mono-, di- and trihydroxyethylated) head group analogues. Their micellization characteristics in water and thermodynamic and structural aspects of water-in-oil microemulsion formed with them along with n-hexanol and isooctane. J. Phys. Chem. B 2006, 110, 11314-11326.
21. Antara Dasgupta, Rajendra Narayan Mitra, Sangita Roy and Prasanta Kumar Das*. Asymmetric Resolution in Ester Reduction by NaBH4 at the Interface of Aqueous Aggregates of Amino Acid, Peptide, and Chiral Counter-ion based Cationic Surfactants. Chem. Asian J. 2006,1, 780-788 (in the Cover Page).
20. Kallol Mohanta, Amlan J. Pal*, Sangita Roy and Prasanta Kumar Das*. A Control Over Accessibility of Immobilized Enzymes Through Porous Coating Layer. J. Colloid Interface Sci. 2006, 304, 329-334.
19. Debapratim Das, Sangita Roy, Rajendra Narayan Mitra, Antara Dasgupta, and Prasanta Kumar Das*. Head group size or hydrophilicity of surfactant: the major regulator of lipase activity in cationic w/o microemulsions. Chem. Eur. J. 2005, 11, 4881-4889 (in the Cover Page).
18. Rajendra Narayan Mitra, Antara Dasgupta, Debapratim Das, Sangita Roy, Sisir Debnath, and Prasanta Kumar Das*. Geometric Constraints at the Surfactant Head Group: Effect on Lipase Activity in Cationic Reverse Micelle. Langmuir 2005, 21, 12115-12123.
17. Sangita Roy, Debapratim Das, Antara Dasgupta, Rajendra Narayan Mitra, and Prasanta Kumar Das*. Amino Acid Based Cationic Surfactants in Aqueous Solution: Physicochemical Study and Application of Supramolecular Chirality in Ketone Reduction. Langmuir 2005, 21, 10398-10404.
16. Antara Dasgupta, Debapratim Das, and Prasanta Kumar Das*. Reactivity of trypsin in reverse micelles: neglected role of aggregate size compared to water-pool components. Biochimie 2005, 87, 1111-1119.
15. Antara Dasgupta, Debapratim Das, Rajendra Narayan Mitra, and Prasanta Kumar Das*. Surfactant tail-length dependent lipase activity profile in cationic water-in-oil microemulsions. J. Colloid Interface Sci. 2005, 289, 566-573.
14. Debapratim Das, Sangita Roy and Prasanta Kumar Das*. Efficient and Simple NaBH4 reduction of esters at cationic micellar surface. Org. Lett. 2004, 6, 4133-4137.
13. Debapratim Das and Prasanta Kumar Das*. Improving the lipase activity profile in cationic water-in-oil microemulsions of hydroxylated surfactants. Langmuir 2003, 19, 9114-9119.
12. Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao, Arabinda Chaudhuri. Novel cationic transfection lipids for use in liposomal gene delivery. Surfactant Science Series (Marcel Dekker) 2003, 603-618.
11. Prasanta Kumar Das, Jose M. M. Caaveiro, Susana Luque and Alexander M. Klibanov. Binding of hydrophobic hydroxamic acids enhances peroxidase’s stereoselectivity in nonaqueous sulfoxidations. J. Am. Chem. Soc. 2002,124, 782-787.
10. Prasanta Kumar Das, Jose M. M. Caaveiro, Susana Luque and Alexander M. Klibanov. Asymmetric sulfoxidations mediated by -chymotrypsin. Biotechnology and Bioengineering 2002, 78, 104-109.
9. Xie Yuchun, Prasanta Kumar Das, Jose M. M. Caaveiro, and Alexander M. Klibanov. Unexpectedly enhanced stereoselectivity of peroxidase-catalyzed sulfoxidations in branched alcohols. Biotechnology and Bioengineering 2002, 79, 105-111.
8. Xie Yuchun, Prasanta Kumar Das and Alexander M. Klibanov. Excipients activate peroxidases in specific but not in nonspecific reactions in organic solvents. Biotechnology Letters 2001, 23, 1451-1454.
7. Prasanta Kumar Das and Arabinda Chaudhuri. On the origin of unchanged lipase activity profile in cationic reverse micelles. Langmuir 2000, 16, 76-80.
6. Prasanta Kumar Das and Arabinda Chaudhuri. Are the interfacial basicities of aqueous cationic micelles and cationic reverse microemulsions different by orders of magnitude? Langmuir 1999, 15, 8771-8775.
5. Prasanta Kumar Das and Arabinda Chaudhuri, Satyen Saha and Anunay Samanta. First simultaneous estimates of the water pool core size and the interfacial thickness of a cationic water-in-oil microemulsion by combined use of chemical trapping and time resolved fluorescence quenching. Langmuir 1999, 15, 4765-4772.
4. Prasanta Kumar Das, Gollapudi Venkata Srilakshmi and Arabinda Chaudhuri. Experimental probing of water and counterion concentrations inside a reversed micelle water-pool: An overlooked parameter in micellar enzymology. Langmuir 1999, 15, 981-987.
3. Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and Arabinda Chaudhuri. Novel series of Non-glycerol based cationic transfection lipids for use in liposomal gene delivery. J. Med. Chem. 1999, 42, 4292-4299.
2. Rajkumar Banerjee#, Prasanta Kumar Das#, and Arabinda Chaudhuri. Interfacial Indazolization: novel chemical evidence for remarkably high exo-surface pH of cationic liposome used in gene transfection. Biochim. Biophys. Acta (Biomembrane) 1998, 1373, 299-308. (# authors contributed equally).
1. Prasanta Kumar Das, Arabinda Chaudhuri, Thengumpillil Narayana Balagopala Kaimal and Uday Triambakaraj Bhalerao. Isolation of g-Oryzanol through calcium ion induced precipitation of anionic micellar aggregates. J. Agric. Food Chem. 1998, 46, 3073-3080. |
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Both in BS-MS and IntPBS Program.
Course Code: BS-40005/BIS-4102: Metabolism & Function: Carbohydrate & Lipid
Course Code: BS-4111: Project Based Biology Laboratory
Course Code: BS-50002/BIS-5204: Delivery of Bioactives
Course Code: BIS-5189 & BIS-5289: – Project
Course Code: BIS-5199 & BIS-5299: - Project
Course Code: BS-49001: Chemical Biology Laboratory
Course Code: BS-57001& 57002 – Project
Course Code: BS-58002 - Viva voce; BS-58004 – Seminar
Membership of Professional Bodies
Patents:
1. Prasanta Kumar Das, Arabinda Chaudhuri, Thengumpillil Narayana Balagopala Kaimal and Uday Triambakaraj Bhalerao. Process of the isolation of g-Oryzanol from crude dark acid oil (rice bran). US Patent No. US 5869708 (granted 1999); Indian Patent No. 183660 (granted 2000)
2. Prasanta Kumar Das, Rajkumar Banerjee, Nalam Madhusudhana Rao and Arabinda Chaudhuri. A preparative process for novel non-glycerol based cationic amphiphiles for intracellular delivery of biologically active molecules. Indian Patent Application No. 3325/DEL/98.
3. Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and Arabinda Chaudhuri. Novel non-glycerol based cationic amphiphiles for intracellular delivery of biologically active molecules.
Process patent: US Patent No. US 6,333,433 B1 (granted 2001).
Product patent: US Patent No. US 6,346,516 B1 (granted 2002).
4. Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and Arabinda Chaudhuri. Cationic amphiphiles containing N-hydroxyalkyl group: delivery of biologically active molecules. US Patent No. US 6503945 (granted 2003).
5. Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and Arabinda Chaudhuri. Process for synthesis of novelcationic amphiphiles containing hydroxyalkyl group for intracellular delivery of biologically active molecules. US Patent No. US 6541649 (granted 2003)
Prof. Prasanta K Das
School of Biological Sciences (Earlier, Department of Biological Chemistry)
Indian Association for the Cultivaion of Science
Jadvpur, Kolkata - 700032, India
Phone:+91 33 2473 4971 (Ext 1505)
Fax: +91 33 2473 2805
E-mail :bcpkd@iacs.res.in/das.prasantak@gmail.com
Name - Year of PhD
Dr. Debapratim Das - 2007 (Professor, IIT Guwahati)
Dr. Antara Dasgupta - 2008 (Senior Executive, Eris LifeSciences Ltd., Guwahati)
Dr. Rajendra N. Mitra - 2008 (Asst. Professor, University of North Carolina, USA)
Dr. Sangita Roy - 2009 (Assoc. Professor, INST, Mohali)
Dr. Sisir Debnath - 2010 (Asst. Professor, Serampore College, Hooghly)
Dr. Dibyendu Das -2010 (Associate. Professor, IISER, Kolkata)
Dr. Anshupriya Shome -2011 (Asst. Professor, BKC College, Kolkata)
Dr. Sounak Dutta - 2012 (Asst. Professor, Ananda Mohan College, Kolkata)
Dr. Subhabrata Maiti - 2013 (Asst. Professor, IISER, Mohali)
Dr. Tanmoy Kar -2013 (Asst. Professor, YSP College, Purba Medinipur)
Dr. Sayanti Brahmachari -2014 (Post-Doc, Italian Institute of Technology, Genova)
Dr. Subhra Kanti Mandal - 2015 (Asst. Professor, Degree College, Darjeeling)
Dr. Moumita Ghosh - 2016 (Asst. Professor, Techno India, Kolkata)
Dr. Deep Mandal - 2017 (NPDF, Jadavpur University)
Dr. Krishnendu Das - 2017 (Post-Doc, University of Padova, Italy)
Dr. Saheli Sarkar - 2019 (UGC Kothari Fellow, Calcutta University)
Dr. Pritam Choudhury - 2020 (Associate, HPCL)
Dr. Soumik Dinda - 2020 (NPDF, JNCASR)
Dr. Debayan Chakraborty - 2022 (IOCL)
Dr. Deblina Sarkar - 2023 (Wiley-VCH)
Dr. Anup Kumar Ghosh - 2024 (Central Revenue Control Laboratory, CRCL)
