Imagining and Imaging- Examples from Materials Science
Structures and many related concepts in material systems were originally â€œvisualisedâ€ by human imagination. Materials scientists are not satisfied by only validating these concepts on the basis of fundamental physical laws but attempt to image them for comparing their imagination with realities. This point will be elaborated citing several examples. It will be shown that modern electron microscopic and atom-probe techniques can indeed image structures in different length scales right upto atomic dimensions. Such observations not only confirm the relevant ideas proposed earlier but also provide a new insight into the governing phenomena. Examples will include dislocations in complex alloys with unit cells containing several hundred atoms, internal twinning of martensite, ordered structures of grain boundaries, partial collapse of lattice planes in a displacement ordering process and atom positions in an interstitially ordered alloy.
Title: Development of a Green & Sustainable Manufacturing Process for MK-7264
Speaker Dr. Kallol Basu
Time: C. V. Raman Halll, 28th november 2018 (4.00-5.30 pm)
MK-7264 is a P2X3 antagonist that is currently being interrogated in Ph3 for Chronic cough. While the old synthetic route was effective for the synthesis of multi-kilo API, it was deemed unsuitable for the preparation of API on metric ton scale.
The evolution of a short, safe, cost-effective and robust process that has been successfully demonstrated on large scale will be discussed.