Laboratory of Molecular & Cellular Biology(LMCB)
Our research interest is to understand the molecular mechanism of basic cellular processes such as dedifferentiation, neuritogenesis, migration, and cell division.
Recently, we have established that transformed cells, due to the exposure of carcinogen,3-MC, show expression of Vimentin, α-SMA, CD34 along with NM IIs. NMIIs can localize at the perinuclear region besides its location at stress fibre and filopodia. At perinuclear site, interaction of NM IIs with Nesprin2 regulate gene expression, which may generate mechanoreciprocity in cancer cells. [Saha et al (2011), Dey et al (2013), Halder et al (2019)]
During cellular migration, cells can adopt lamellipodia or blebbing membrane protrusive activity. Mode of migration of a cell can be fine-tuned by the amount of NM II activity which is regulated by Rho/Rac signaling pathway. [Dey and Singh et al (2017) and unpublished observation].
Recent finding of alternative splicing in loop 2 of NM IIs in neuronal cells suggest the functional importance of NM IIs in neurogenesis. [Saha et al (2013), Saha et al (2017) and unpublished observation].
Our working hypothesis