Laboratory of Molecular & Cellular Biology(LMCB)
The Laboratory of Molecular and Cellular Biology works on the gene regulation, protein chemistry, molecular interaction and signalling pathways to understand the various cellular functions such as adhesion, division and migration which are basic fundamental processes in a living system. Our protein of interest is Non-muscle Myosin II (NM II) which is ubiquitously expressed in mammals. We wish to investigate 1) the genetic regulation of Myosin II by mi-RNAs, lnc-RNA, 2) the splicing mechanism of NM II heavy chain pre-mRNAs in neuronal cells, 3) the signalling pathways for cellular transformation, cellular migration, vesicle trafficking and mechanosensing, 4) the delivery of drug into the cell. We use mouse model for in vivo and variety of cell lines for in vitro studies.
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