We are interested in developing different spectroscopic techniques to study the molecular level phenomena in order to elucidate the fundamental physical/chemical processes behind several complexed biophysical processes such as protein folding, blood coagulation, solvation behavior of fluorocarbon containing amino acids and DNAs.
Fluorocarbons possess unusual but useful physicochemical properties. Molecules containing fluorocarbon group(s) have garnered significant interest because of its implication in the de novo designed proteins, fire retardants and anesthetics. It has been found that fluorine substituted proteins stabilize its native structure in the guanidium chloride, organic solvents and urea more as compared to unsubstituted proteins without affecting much to its biological activity. Our interest is to find a molecular level understanding about the nature of interaction and local environments which causes the fluorine containing proteins and DNAs to show such interesting role in biology.
(b) Role of membrane interfaces in the coagulation using SFG techniques
Our group is interested to understand the behavior of soft interfaces such as air/water and membrane interfaces using the spectroscopic techniques. Such interfaces are important as several biological and environmental processes takes place at these soft interfaces. We are currently trying to understand the complex biological processes such as protein folding, protein-DNA interaction as well as role of interfacial water in the blood coagulation phenomena using surface selective vibrational and electronic spectroscopy techniques.
(c)Aerosol formation at the air/water interfaces
Aerosol particle plays an important role in earth’s troposphere and climate change. Aerosol particle form the cluster and have the ability to grow faster , known as nucleation. Several ions and the gases along with the air/water interface plays an important role in the sea aerosol formation. We are interested to know the structural growth of the aerosol as well as role of interfaces in the formation of aerosol particles.