Nanobiotechnology: We work at the interface of chemistry, biology and materials science. We design colloidal nanoparticle and nanobioconjugate with controlled size and surface chemistry, study interaction with live cell, endocytotic uptake vs direct membrane penetration and subcellular targeting property. We design/develop sub-cellular imaging nanoprobe, reactive oxygen species generating nanoparticle for cell therapy, nanodrug for inhibiting protein aggregation in cell model and clearing amyloid aggregates from cell via autophagy induction, piezocatalytic nanoparticle for sound-based cell therapy, nanomotors for crossing of blood-brain barrier, nanocarrier for nucleus/mitochondria targeting of molecular drug and 2D surface for sunlight/sound-induced anti-bacterial property.

See Our Works in ACS Live Slides:

11) Arginine-Terminated Nanoparticles of <10 nm Size for Direct Membrane Penetration and Protein Delivery for Straight Access to Cytosol and Nucleus. https://pubs.acs.org/doi/10.1021/acs.jpclett.0c00176

10) Vitamin C-Conjugated Nanoparticle Protects Cells from Oxidative Stress at Low Doses but Induces Oxidative Stress and Cell Death at High Doses

9) Quantum Dot-Based Designed Nanoprobe for Imaging Lipid Droplet

8) Nitrogen and Fluorine Codoped, Colloidal TiO₂  Nanoparticle: Tunable Doping, Large Red-Shifted Band Edge, Visible Light Induced Photocatalysis, and Cell Death

7) Supramolecular Host-Guest Chemistry-Based Folate/Riboflavin Functionalization and Cancer Cell Labeling of Nanoparticles

6)Poly(trehalose) Nanoparticles Prevent Amyloid Aggregation and Suppress Polyglutamine Aggregation in a Huntington Disease Model Mouse

5) Multivalency Effect of TAT-Peptide-Functionalized Nanoparticle in Cellular Endocytosis and Subcellular Trafficking

4)Sugar-Terminated Nanoparticle Chaperones Are 10²-10⁵Times Better Than Molecular Sugars in Inhibiting Protein Aggregation and Reducing Amyloidogenic Cytotoxicity

3) Efficient Inhibition of Protein Aggregation, Disintegration of Aggregates, and Lowering of Cytotoxicity by Green Tea Polyphenol-Based Self-Assembled Polymer Nanoparticles

2) Nanoparticle Multivalency Directed Shifting of Cellular Uptake Mechanism

1) Clathrin to Lipid Raft-Endocytosis via Controlled Surface Chemistry and Efficient Perinuclear Targeting of Nanoparticle