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» Structure and Dynamics: Spectroscopy and Scattering (SDSS - 2023) » Admission to Integrated Bachelor's-Master's Program in Science and Master's/Integrated Master's-Ph.D. Program in Science - 2023NEW

Name : Surajit Sinha

Deptartment : School of Applied & Interdisciplinary Sciences
Designation : Senior Professor
Contact : +91 33 2473 4971 (Ext:1400)
Email : ocss5@iacs.res.in
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 Sinha's Group

Group with Prof. S. Chandrasekaran in Feb 2020

 

 

Research interests: Organic Synthesis, Chemical Biology, Drug discovery and delivery

  • Synthesis of biologically important natural products and their analogues.
  • Studies of small molecule modulation of Hedgehog signaling pathway in tissue culture and studies of Hedgehog dependent physiology using “zebrafish (Danio rerio) as a model organism.
  • Synthesis of artificial amino acids and nucleic acids for biological probes.
  • Synthesis and evaluation of antisense properties of cell-penetrating morpholino oligonucleotides in cancers targeting hedgehog signaling pathway
  • Non-peptide-based molecular transporter used for drug, peptide and biomolecules delivery.
  • Antisense-based therapy for the treatment of Duchenne muscular dystrophy (DMD)

Patents

  • Sinha, S.; Pattanayak, S.; Paul, S.; Nandi, B.  Morpholino based antisense agent. WO 2011/018798, Granted US 9,914,745B2, date of patent March 13, 2018.
  • Sinha, S.; Pattanayak, S. Substituted Internal Ologo-Guanidines As Cellular Penetrating Agents. 71/KOL/2013 dated 21 January 2013.
  • Sinha, S.; Das, S.; Banerjee, T.; Paul, S. Isoquinuclidine Derivatives as Antinociceptive Agents for Pain Relief. 946/KOL/2014 dated 16.09.2014.
  • Sinha, S.; Bhadra, J.; Pattanayak, S.; Kundu, J. OLIGO-GUANIDINES composed of heterocyclic rings with hydrophobic/ lipophilic group at the N-terminal based cellular transporter for effective delivery of nonpenetrable cargos in vitro and in vivo 1328/KOL/2015, 23.12.2015.
  • MMTr-protected H-phosphonate monomers and MMTr-deprotection by organic acids are the right combination of morpholino oligonucleotides synthesis (Patent Application No. as 2016310


Academic Profile

Education:

Int. PhD (M.S. and PhD) (2000): Indian Institute of Science (IISc), Bangalore, (Under Professor S. Chandrasekaran, Department of Organic Chemistry).

Professional:

  • Postdoctoral Fellow (2000-2003): Department of Chemistry, University of California, Riverside, in NASA Astrobiology Program (Advisor: Professor Christopher Switzer).
  • Postdoctoral Fellow (2003-2006 March): Chemical and Systems Biology, School of Medicine, Stanford University, (Advisor: Professor James K. Chen).
  • Assistant Professor (April 2006 – January2012): Indian Association for the Cultivation of Science, Kolkata, India.
  • Associate Professor (January 2012 – January 2017): Indian Association for the Cultivation of Science, Kolkata, India. 
  • Professor (Jan 2017 to till date)


Group

Dr. Pallab Shaw

Research Associate
Morpholino based antisense therapy. Ph.D Visva-Bharati (2021)                    M. Sc. The Unisversity of Burdwan (2013)                                                Date of Joining: October, 2021. pallabshaw@gmail.com
Chandra Bose

DST-WOS A
Regulation of Hedgehog Signaling Pathway using small molecules and antisense oligonucleotides. M.Sc. Calcutta University B. Sc. St. Xavier’s College Slowest foodie of the group. Handles large earrings and Zebrafish embryos equally deftly. Date of joining: June, 2017 occb@iacs.res.in
Ujjwal Ghosh

Senior Research Fellow
Development of new chemistry towards the synthesis of Morpholino Oligonucleotides. M. Sc. Guru Ghasidas Vishwavidyalaya B. Sc. R.S. Mahavidyalaya. Loves to do column chromatography and characterizes products efficiently with just a few milligrams. Date of joining: November, 2017 ocug@iacs.res.in
Shalini Gupta

Senior Research Fellow (CSIR)
Synthesis of non-peptide based delivery agents, ideally non-toxic, and their biological efficacy. M.Sc. IACS (Int. PhD) B.Sc. Lady Brabourne College An OCD patient with respect to cleanliness and organized things. Date of joining: June, 2018 intsg2@iacs.res.in
Abhishek Gupta

Senior Research Fellow
Development of Azaproline based peptides and delivery agents.
M. Sc. IACS (Int. PhD)
B. Sc. Scottish Church College
Four C’s of his life: Chemistry, Chicken, Carrom and Cricket (never plays though). Standardizes reactions slowly, steadily and with resilience.
Date of joining: June, 2018
intag@iacs.res.in
Arnab Das

Senior Research Fellow(CSIR)
Synthesis of Functionalized Morpholino Oligonucleotides. M. Sc. IACS (Int. PhD) B. Sc. Vivekananda College Mimicry artist of the group. DCM runs through his veins instead of blood. Date of joining: July, 2019 intad2@iacs.res.in
Atanu Ghosh

Senior Research Fellow (CSIR)
Synthesis of Functionalized Morpholino Oligonucleotides. M. Sc. IACS (Int. PhD) B. Sc. City College Loves cricket. On the pitch, an all rounder. Off the pitch, loves to take clean NMR spectra. Date of joining: July, 2019 intag3@iacs.res.in
Swrajit Nath Sharma

      Junior Research Fellow           Synthesis of IGT and evaluation of biological efficacy M.Sc IACS (Int. PhD) Bsc. Debrugarh University Focused, humble and witty, with keen intrest in Chemistry an passionate about dancing. Date of joining: September, 2021 swrajitn@gmail.com
Sudipta Sarkar

Junior Research Fellow(CSIR)
Oncoimmunotherapy M.Sc, Rajabazar Science College, University of Calcutta B.Sc.: Hooghly Mohsin College, The Unisversity of Burdwan Date of joining: February, 2022 sudiptasarkar903@gmail.com
Md. Qasim


Junior Research Fellow (UGC)
Development of Internal Oligo-guanidinium Transporter (IGT)
M. Sc. IACS (Int. PhD)
B. Sc. Maulana Azad College
Funny and serious. Calm and mischievous. He is not at all what you think he is.
Date of joining: August 2022
mdq789@gmail.com
Subhamoy Pratihar

Junior Research Fellow             Synthesis of Morpholino Oligonucleotides and lboga analogues. M.Sc. IACS (Int.PhD) B. Sc. Bankura Sammilani College Vivacious manager and go-to person of the group. Also a night owl and a comic Date of joining: August, 2022 subhamoypratihar@gmail.com
Arpan Banerjee


MS-1st Year
Synthesis of Antisense Morpholino oligonucleotides.
B. Sc. IACS
Youngest and modest with the cutest smile. That junior who is impossible to scold at.
Date of joining: August, 2022
arpan.bqa@gmail.com

 

Publications
 

2022

Das, O.; Kundu, J.; Ghosh, A.; Gautam, A.; Ghosh, S.; Chakraborty, M.; Masid, A.; Gauri, S. S.; Mitra, D.; Dutta, M.; Mukherjee, B.; Sinha, S.; Bhaumik, M. AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring 1 AUF-1-Dicer-1-miR122 hierarchy. bioRxiv 2022, https://doi.org/10.1101/2022.06.13.496022
 

2022

Gupta, A.; Gupta, S.; Das, U. and Sinha, S. Guanidinium Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro. Bioconjugate Chem. 2022, 33, 907-917 https://doi.org/10.1021/acs.bioconjchem.2c00129
 

2022

J. Kundu, A. Ghosh, U. Ghosh, A. Das, D. Nagar, S. Pattanayak, A. Ghose and S. Sinha: Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry in an Automated Oligo Synthesizer. J. Org. Chem. 2022, 87, 15, 9466–9478 https://doi.org/10.1021/acs.joc.2c00265
 

2022

Mana, T.; Kundu, J.; Lahiri, H.; Bera, S.; Kolay, J.; Sinha, S.; Mukhopadhyay, R. Molecularly Resolved, Label-free Nucleic Acid Sensing at Solid-liquid Interface using Non-ionic DNA Analogues. RSC Adv. 2022, 12, 9263-9274

 
 

2022

Bose, C.; Das, U.; Kuilya, T. K.; Mondal, J.; Bhadra, J.; Banerjee, P.; Goswami, R. K. and Sinha, S. Cananginone Abrogates EMT in Breast Cancer Cells through Hedgehog Signaling. Chem. Biodiversity 2022, e202100823 (https://doi.org/10.1002/cbdv.202100823)
 

2022:

Gupta, S.; Qasim, Md.; Gupta, A.; Kundu, J.; Sinha, S. Structural Modifications to the Internal Oligoguanidinium Transporter Uncover Two Potent Analogues that Effectively Deliver the Pro-apoptotic Peptide in Multiple Cancer Cell Lines. Bioconj. Chem. 2022, 33 (1), 121-133, doi.org/10.1021/acs.bioconjchem.1c00456

 
 

2021

Kundu, J.; Das, U.; Bose, C.; Bhadra, J. and Sinha, S. Self-transfecting GMO-PMO and PMO-GMO chimeras enable gene silencing in vitro and in vivo zebrafish model and NANOG Inhibition Induce the Apoptosis in Breast and Prostate Cancer Cells. BioRxiv 2021, https://doi.org/10.1101/2021.06.04.447039

 
 

2021

Banerjee, I. ; Ghosh, K. C. ; Oheix, E. ; Jean, M.; Naubron, J-V.; Réglier, M.; Iranzo, O.* and Sinha, S.* Synthesis of Protected 3,4- and 2,3-Dimercaptophenylalanines as Building Blocks for Fmoc-Peptide Synthesis and Incorporation of the 3,4-Analogue in a Decapeptide Using Solid-Phase Synthesis. J. Org. Chem. 2021, 86, 2210−2223, doi.org/10.1021/acs.joc.0c02359.

 

2020

Chandra Bose, Priyanjalee Banerjee, Jayanta Kundu, Biswadeb Dutta, Indranil Ghosh, Shreya Sinha, Argha Ghosh, Abhishek Barua, Shalini Gupta, Ujjal Das, Siddhartha S. Jana, Surajit Sinha. Evaluation of tubulin targeted pyrimidine indole hybrid molecule as an anticancer agent. ChemSelect 2020, 5, 14021‒14031.

J. Kundu, P. Banerjee, C. Bose, U. Das, U. Ghosh and S. Sinha: Internal Oligoguanidinium Transporter: Mercury Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitisation of Taxol in MCF-7 Cells. Bioconj. Chem. 2020, 31 (10), 2367‒2382, doi.org/10.1021/acs.bioconjchem.0c00444.

J. Kundu, U. Ghosh, A. Ghosh, A. Das, D. Nagar, A. Ghose and S. Sinha: Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry-A New Method Amenable to Automated Synthesizer. ChemRxiv 2020, 10.26434/chemrxiv.12765563

 
 

Ghosh, K. C.; Duttagupta, I.; Bose, C.; Banerjee, P.; Gayen, A. K. and Sinha, S. Synthesis and anti-cancer activities of prolein-containing cyclic peptides and their linear analogs and congeners Syn. Commun. 2019, 49, 221‒236.  

 

 
 

Ghosh K. C.; Banerjee, I. And Sinha, S. Montrillonite K 10 catalysed highly regioselective azidolysis of epoxides. A short and efficinat synthesis of phenylglycine. Syn. Commun. 2018, 48, 2923‒2934.

 
 
Khatra, H.; Khan, P. P.; Pattanayak, S.; Bhadra, J.; Rather, B.; Chakrabarti, S.; Saha, T. and Sinha, S. Hedgehog antagonist pyrimidine-indole-hybrid molecule inhibits ciliogenesis through microtubule destabilization. ChemBioChem 2018, 19, 723–735.
 
Nandi, B.; Khatra, H.; Khan, P. P.; Bhadra, J.; Pattanayak, S. and Sinha, S. “Cationic Cytosine Morpholino-Based Transporters: Synthesis and Regulation of Intracellular Localization”. ChemSelect 2017, 2, 5059–5067.
 
Khatra, H.; Bose, C. and Sinha, S. "Discovery of hedgehog antagonists for cancer therapy". Current Med. Chem. 2017, 24, 1–26, invited review).
 
Bhadra, J.; Pattanayak, S.; Khan, P. P.; Kundu, J.; Sinha, S. “Internal Oligoguanidinium-based Cellular Transporter Enhances Antisense Efficacy of Morpholinos in in vitro and Zebrafish model”. Bioconjugate Chem. 2016, 27, 2254–2259.
 
Khatra, H.; Kundu, J.; Khan, P. P.; Duttagupta, I.; Pattanayak, S. and Sinha, S. “Piperazic Acid Derivatives Inhibit Gli1 in Hedgehog Signaling Pathway”. Bioorg. Med. Chem. Lett. 2016, 26, 4423–4426.
 
Duttagupta, I.; Bhadra, J.; Das, S. K.; Sinha, S. “Proteolytic stability of α-hydrazino acid-containing peptides: a qualitative study”. Tetrahedron Lett. 2016, 57, 3858–3861.
 
Duttagupta, I.; Ghosh, K. C.; Sinha, S. “Synthetic Studies Toward Nonribosomal Peptides”. Studies in Natural Product Chem. (Elsevier, UK) (Elsevier, UK) 2016, 48, 31–66 (invited).
 
Duttagupta, I.; Misra, D.; Bhunya, S.; Paul, A.; Sinha, S. “Cis - Trans Conformational Analysis of δ – Azaproline in Peptides”. J. Org. Chem. 2015, 80, 10585−10604.
 
Bhadra, J.; Pattanayak, S. “Synthesis of Morpholino Monomers, Chlorophosphoramidate Monomers and Solid Phase Synthesis of Short Morpholino Oligomers”. Current Protocols in Nucl. Acid Chem. 2015, 4.65.1–4.65.26 (Wiley).
 
Bhadra, J.; Kundu, J.; Ghosh, K.; Sinha, S. “Synthesis of phosphorodiamidate morpholino oligonucleotides by H-phosphonate method”. Tetrahedron Lett. 2015, 56, 4565–4568.
 
Banerjee, T. S.; Paul, S.; Sinha, S.*; Das, S.* “Synthesis of iboga-like isoquinuclidines: Dual opioid receptors agonists having antinociceptive properties”. Bioorg. Med. Chem. 2014, 22, 6062–6070.
 
Chakraborty, A.; Jyothi, K.; Sinha, S. “Palladium-catalyzed synthesis of 2-allylindole and 2-allylbenzofuran derivatives from 2-((trimethylsilyl)ethynyl)arenes.” Tetrahedron Lett. 2014, 55, 6795–6798.
 
Duttagupta, I.; Goswami, K.; Chatla, P. and Sinha, S. “Improved Synthesis of Cyclic α-Hydrazino Acids of 5 to 9-Membered Rings and Optical Resolution of 5, 6, 7-Membered Ring Hydrazino Acids” Syn.Commun. 2014, 44, 2510–2519.
 
Paul, S.; Pattanayak, S.; Sinha, S. “Synthesis and Cell Transfection Properties of cationic uracil-morpholinotetramer”. Tetrahedron Lett. 2014, 55, 1072–1076.
 
Pattanayak, S.; Khatra, H.; Saha, S. and Sinha, S. “Cationic Morpholino Antisense Oligomer Conjugate: Synthesis, Cellular uptake and Inhibition of Gli1 in Hedgehog Hedgehog Signalling Pathway” RSC Advances 2014, 4, 1951–1954.
 
Paul, S.; Jana, S.; Bhadra, J.; Sinha, S. “Photophysical Studies and Submicron Ring Formation of Morpholino U-Nucleoside Monomers” Chem. Commun. 2013, 49, 11278–11280.
 
Chakraborty, A.; Goswami, K.; Adiyala, A.; Sinha, S. “Syntheses of Spiro[cyclopent[3]ene-1,3_-indole]s and Tetrahydrocyclo-hepta[b]indoles from 2,3-Disubstituted Indoles through Sigmatropic Rearrangement” Euro. J. Org. Chem. 2013, 7117–7127.
 
Goswami, K.; Chakraborty, A.; Sinha, S. “Synthesis of Optically Active Selenium-Containing Isotryptophan, Homoisotryptophan and Homotryptophan” Euro. J. Org. Chem. 2013, 3645–3647.
 
Nandi, B.; Pattanayak, S.; Paul, S. and Sinha, S. “Synthesis of Nucleobase-Functionalized Morpholino Modified Nucleoside Monomers Through Palladium-Catalyzed Cross-Coupling Reactions” Euro. J. Org. Chem. 2013, 1271–1286.
 
Pattanayak, S.; Paul, S.; Nandi, B. and Sinha, S. “Improved protocol for the synthesis of Flexibly ProtectedMorpholino Monomers from Unprotected Ribonucleosides” Nucleosides, Nucleotides and Nucleic Acids 2012, 31, 763–782.
 
Pattanayak, S.; Sinha, S. “Lithium bromide–DBU mediated synthesis of chlorophosphoramidate-activatedmorpholino nucleoside subunits” Tetrahedron Lett. 2012, 53, 6714–6717.
 
Duttagupta, I.; Goswami, K.; Sinha, S. “Synthesis of cyclic α-hydrazino acids” Tetrahedron 2012, 68,8347–8357.
 
Jana, G. K. and Sinha, S. “Total synthesis of ibogaine, epiibogaine and their analogues” Tetrahedron 2012,68, 7155–7165.
 
Paul, S.; Nandi, B.; Pattanayak, S.; Sinha, S. “Synthesis of 5-alkynylated uracil–morpholino monomersusing Sonogashira coupling” Tetrahedron Lett. 2012, 53, 4179–4183.
 
Jana, G. K. and Sinha, S. “Reductive Heck coupling: an efficient approach toward the iboga alkaloids.Synthesis of ibogamine, epiibogamine and iboga analogs” Tetrahedron Lett. 2012, 53, 1671-1674.
 
Goswami, K.; Duttagupta, I.; Sinha, S. “Synthesis of optically active homotryptophan and its oxygen andand sulfur analogues” Tetrahedron 2012, 68, 280–286.
 
Goswami, K.; Duttagupta, I.; Sinha, S. “Synthesis of Optically Active 2- and 3-Indolylglycine derivatives and their Oxygen Analogues” J. Org. Chem. 2012, 77, 7081−7085.
 
Pattanayak, S.; Sinha, S. “Ceric ammonium nitrate-mediated detritylation of tritylated amines” TetrahedronLett. 2011, 52, 34–37.
 
Paul, S.; Pattanayak, S.; Sinha, S. “Synthesis of new series of iboga analogues” Tetrahedron Lett. 2011,52, 6166–6169.
 
Chakraborty, A.; Sinha, S. “Synthesis of 3-[2-(1,3-butadienyl)]-1H-indoles en route to murrapanineanalogue” Tetrahedron Lett. 2011, 52, 6635–6638.
 
Jana, G. K.; Paul, S.; Sinha, S. “Recent Progress in the Synthesis of Iboga-alkaloids and their congeners”Org. Prep. Proc. International (Invited Review) 2011, 43, 541–573.
 
Nandi, B.; Sinha, S. “Alkylation of acylmetalates with alkyl halides to prepare Fischer carbine complexes:an improved protocol” Tetrahedron 2011, 67, 106–113.
 
Jana, G. K.; Sinha, S. “Synthesis of iboga alkaloids by Pd-catalyzed heteroannulation of 2-iodoaniline with an internal alkyne as the key step” Tetrahedron Lett. 2010, 51,1441–1443.
 
From IACS: Jana, G. K.; Sinha, S. “A concise route to iboga-analogues via the formation of suitably substituted-2-indoles” Tetrahedron Lett. 2010, 51, 1994–1996.
 
Hyman, J. M.; Firestone, A. J.; Heine, V. M.; Zhao, Y.; Ocasio, C. A.; Han, K.; Sun, M.; Rack, P. G.; Surajit Sinha; Wu, J. J.; Solow-Cordero, D. E.; Jiang, J.; Rowitch, D. H.; James K. Chen. “Small-molecule inhibitors reveal multiple Strategies for Hedgehog pathway blockade” Proc. Natl. Acad. Sci USA 2009, 106,14132 – 14137.
 
Ouyang, X.; Shestopalov, I. A.; Surajit Sinha, Zheng, G.; Pitt, C. L. W.; Li, W. H.; Olson, A. J.; James K. Chen. “Versatile Synthesis and Rational Design of Caged Morpholinos” J. Am. Chem. Soc. 2009, 131, 13255–13269.
 
Cupido, T.; Rack, P. G.; Firestone, A. J.; Hyman, J. M.; Han, K.; Surajit Sinha; Ocasio, C. A. and James K. Chen. “The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling.” Angew. Chem. Int. Ed. 2009, 48, 2321 – 2324.
 
Shestopalov, I. A.; Sinha, S.; Chen, J. K. “Light-controlled gene silencing in zebrafish embryos”. Nature Chemical Biology. 2007, 3, 650 - 651. (Authors contributed equally). (It was cited by the Faculty of 1000 as a "must read" with an F1000 factor of 6.4 and won ‘2008 NIH Pioneer Awards’).
 
Sinha, S.; Chen, J. K. “Purmorphamine activates the hedgehog pathway by targeting smoothened”. Nature Chemical Biology. 2006, 2, 29 – 30. (Work appeared as news and views in this issue).
 
Switzer, C.; Sinha S.; Kim, P. H.; Heuberger, B. D. “A purine-like Nickel (II) base-pair for DNA”. Angew. Chem. Int. Ed. 2005, 44, 1529 – 1532. (Hot off the Press, Mol. BioSyst. 2005, 1, 109-111).
 
Sinha S.; Kim, P. H.; Switzer, C. “2’-5’-linked DNA is a template for polymerase-directed DNA synthesis J. Am. Chem. Soc. 2004, 126, 40-41.
 
Post doctoral work: Chaput, J. C.; Sinha, S.; Switzer, C. “5-Propynyluracil diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA”. Chem. Commun. 2002, 1568-1569.
 
Sinha, S.; Tilve, S.; Chandrasekaran, S. “A convenient synthesis of trans-3-hydroxy-L-proline” ARKIVOC (Gainesville, FL, United States). 2005, 11, 209-217.
 
Bhat, R. G.; Sinha, S.; Chandrasekaran, S. “Propargyloxycarbonyl (Poc) amino acid chlorides asefficient coupling reagents for the synthesis of 100% diastereopure peptides and resin boundtetrathiomolybdate as an effective deblocking agent for the Poc group”. Chem. Commun. 2002, 812-813.
 
Sridhar, P. R.; Sinha, S.; Chandrasekaran, S. “Highly selective deprotection of tert-butyl estersusing ytterbium triflate as a catalyst under mild conditions”. Indian Journal of Chemistry, SectionB, 2002, 41B(1), 157-160.
 
Sinha, S.; Mandal, B.; Chandrasekaran, S. “Insertion of ethyl acetate to aromatic compounds by meansof Friedel-Crafts reaction with -chloro--(ethylthio)-acetate catalyzed by ytterbium triflate.” Tetrahedron Lett. 2000, 41, 9109-9112.
 
Sinha, S.; Mandal, B.; Chandrasekaran, S. “Selective para metalation of 3-methoxy and 3,5-dimethoxy benzoic acids with LIC-KOR: synthesis of 3,5-dimethoxy-4-methyl benzoic acid”. Tetrahedron Lett.2000, 41, 3157-60.
 
Sinha, S.; Ilankumaran, P.; Chandrasekaran, S. “The prop-2-ynyloxy carbonyl function (POC):a new amino-protecting group removable from sulfur-containing peptides by ultrasonicirradiation with tetrathiomolybdate under mild and neutral conditions”. Tetrahedron Lett. 1999, 40, 771-774.
 
Ravikumar, K. S.; Sinha, S.; Chandrasekaran, S. “Diastereoselectivity in the reduction of acycliccarbonyl compounds with diisopropoxytitanium(III) tetrahydroborate”. J. Org. Chem. 1999, 64, 5841-5844.
 
1. Sinha, S.; Ilankumaran, P.; Chandrasekaran, S. “One pot conversion of alcohols to disulfides mediated by tetrathiomolybdate”. Tetrahedron. 1999, 55, 14769-14776.

 


Teaching

  • Organic Synthesis-I      Subject Code(s): CHS4203 (for SCS)

    and Oragnic Chemistry-II AIS4201 (for SAIS)/ PHD208
  • Drug Design and Delivery AIS5103; PHD114


Facilities

  • Synthetic Organic Chemistry Lab
  • Oligosynthesizer for RNA/DNA synthesis
  • Molecular Biology and Cell culture Lab
  • Zebrafish Lab


Patent

1) Sinha, S.; Pattanayak, S.; Paul, S.; Nandi, B.  Morpholino based antisense agent. WO 2011/018798, US20120296087; File no. IACS/NPA04/2009; Office filing no. 1059/KOL/2009. International publication date 17.02.2011. US 9,914,745B2, date of patent March 13, 2018

2) Sinha, S.; Pattanayak, S. Substituted Internal Ologo-Guanidines As Cellular Penetrating Agents. 71/KOL/2013 dated 21 January 2013.

3) Sinha, S.; Das, S.; Banerjee, T.; Paul, S. Isoquinuclidine Derivatives as Antinociceptive Agents for Pain Relief. 946/KOL/2014 dated 16.09.2014.

4) Sinha, S.; Bhadra, J.; Pattanayak, S.; Kundu, J. OLIGO-GUANIDINES composed of heterocyclic rings with hydrophobic/ lipophilic group at the N-terminal based cellular transporter for effective delivery of nonpenetrable cargos in vitro and in vivo 1328/KOL/2015, 23.12.2015, PCT/IN2016/000150, 10th June 2016.

Sinha, S.; Kundu, J.; Bhadra, J. MMTr-protected H-phosphonate monomers and MMTr-deprotection by organic acids are the right combination of morpholino oligonucleotides synthesis (Patent Application No. as 201631037420, 2nd November, 2016).

Sinha, S. and Shastry, A. jointly with DART, Bengaluru “IGT Conjugated Antisense Oligonucleotides for inducing exon skipping in Duchenne Muscular Dystrophy.” Ref. No./Application No: 201741040678; App. Number: TEMP/E- 1/41357/2017- CHE


Alumni

Ph.D Awarded and current position:

1) Dr. Goutam Kumar Jana (Pharma Co. ChemBiotek).

2) Dr. Sankha Pattanayak, Postdoctoral Research Associate under Prof. James K. Chen Group, Chemical & Systems Biology, School of Medicine, Stanford University, USA.

3) Dr. Sibasish Paul, Postdoctoral Research Associate under Prof. Marvin H Caruther's group at the Department of Chemistry & Biochemistry, University of Colorado, Boulder, USA. now as a scientist in Agilent Technologies, Colorado, USA. 

4) Dr. Koushik Goswami, Post Doctoral Research Fellow under Dr. Stéphane P. Roche at the Department of Chemistry and Biochemistry, Florida Atlantic University. At present a guest Lecturer in Belur Ramkrishna Mission Vidyamandir and Research Associate by Kothari fellowship (UGC) in Kalyani University. At present Assistant professor in Amity University, Kolkata.

5) Dr. Amrita Chakraborty, Research Associate by Kothari fellowship (UGC) in Visva Bharati University, Santiniketan, W. B. and also a guest lecturer. At present Assistant Professor, A. N. College, Patna

6) Dr. Indranil Duttagupta, Postdoctoral Research Associate under Prof. Gérard Audran in Aix-Marseille University, France. At present Durham University, UK

7) Dr. Bappaditya Nandi, Research Associate in my lab (2015 to till date). At present Assistant Professor in Budge Budge Engineering College, Kolkata

8) Dr. Jhuma Bhadra, Post doctoral fellow at Clemson University, USA (May 2017). At present March 1 st Boston College

9) Dr. Harleen Khatra, Assistant Professor, SUS College of Engineering

10) Dr. Pragya P. Khan (DBT RA-1 for 3 years, Ph.D in Zoology, Visva Bharati University). At present working as a post doc Sunnyvale, California.

11) Dr. Keshab Chandra Ghosh, now at IOCL. 

12) Dr. Priyanjalee Banerjee, (DBT RA-1), now Assisstant Professor, Raiganj Surendranath Mahavidyalaya, Raiganj. 

13) Dr. Isita Banerjee.

14) Dr. Jayanta Kundu, now at Alnylam Pharmaceuticals, USA.

Project Students' Alumni:

1) Ms. Shreya Sinha (IntPhD, SAIS, project duration: July2019-March-2020)

2) Mr. Abhishek Barua (IntPhD, SBS, project duration: June2019-March-2020)

3) Ms. Shayari Bhattacharya (IntPhD, SAIS, project duration: June2020-May-2021)

4) Ms. Firdaus Ahmed (IntPhD, SBS, project duration: June2020-May-2021)

5) Mr. Swapnendu Deb (IntPhD, SAIS, project duration: September2021-June2022)

6) Ms. Neha Poddar (IntPhD, SAIS, project duration: September2021-June2022)


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