Indian Association for the Cultivation of Science

Name : Jyotirmayee Dash

Department : School of Chemical Sciences
Designation : Senior Professor
Contact : +91 33 2473 4971 (Ext:1405)
Email :



Our research is focussed on the structure and function of nucleic acids that can be applied in basic and translational domains.


1. Chemical probe and compound library development: We develop new chemical approaches for organic synthesis and medicinal chemistry to generate naturally occurring alkaloids and drug-like compounds.


2. Use of chemical tools to probe biological systems: The group uses simple synthetic methods to design novel molecular probes like nucleoside derivatives, peptidomimetics, alkaloids and short PNAs for selectively targeting DNA secondary structures and modulating gene expression. A number of probes have been developed that can detect G-quadruplexes in cells.


3. System biology for therapeutic intervention: By modulating the structure and function of nucleic acid targets, new therapeutic tools for diseases like cancer, neurodegenerative disorders, and microbial infections can be made. We have developed Target Guided Synthesis (TGS) approaches employing DNA and RNA secondary structures like G-quadruplexes, i-motifs and HIV-TAR RNA to synthesize their own selective ligands. TGS, a unique bioorthogonal approach, utilizes in situ click chemistry to enable ligand synthesis without interfering or reacting with the native biomolecules present in the system. Recently, we have demonstrated bioorthogonal synthesis of macrocyclic ligands within the cells to modulate gene function.


4. Engineered molecular systems and synthetic biology: We design DNA based ion channels to transport metal ions and drugs across biological membranes. We developed DNA-based logic device to execute programmed function and stimuli responsive i-motif based nanosensors to identify selective ligands. We have also engineered DNA conjugated gold-coated magnetic nanoparticles for developing new tools for analytical applications.These studies would find wide applications in DNA nanotechnology.



Academic Profile

Professor IACS, since 2018.

Associate Professor, IACS, 2014-2018

Assistant Professor, Indian Association for the Cultivation of Science (IACS), Kolkata, 2012-2014

Assistant Professor,  Indian Institute of Science Education and Research (IISER), Kolkata2009-2012

Research Experience

Visiting Fellow, May-July 2010, University of Bristol, UK

(with Professor Stephen Mann, FRS).

Marie-Curie  Fellow, 2007-2009, University of Cambridge, UK

(Research advisor: Professor Sir Shankar Balasubramanian, FRS).

Postdoctoral Fellow, 2006-2007, ESPCI-Paris, France

(Research advisor: Professor Janine Cossy).

Alexander von Humboldt Fellow, 2004-2006, Freie Universität Berlin, Germany

(Research advisor: Professor Dr. Hans-Ulrich Reissig).


Ph.D. (Synthetic Organic Chemistry), Indian Institute of Technology, Kanpur, India, 2003

(Research advisor: Prof.  F. A. Khan).

M.Sc. (Chemistry), Ravenshaw University, Cuttack, India.


Tathagato Bhattacharyya

Integrated M.Sc.(Biotechnology) St. Xavier's College
Joined lab in 2020
Debasmita Biswas

Integrated MSc. (Biotechnology) St. Xaviers College
Joined lab in 2020
Ritapa Chaudhuri

B.Sc. (Biochemistry), University of Calcutta (2013)
M.Sc. (Biochemistry), University of Calcutta (2015)
Joined lab in 2016
Shilpi Karmakar

B. Sc. (Chemistry) Bakura Sammilani College, Burdwan University
M. Sc. (Chemistry) IIT-Kharagpur, 2016
Joined lab in 2016
Raj Paul

B.Sc (Physiology): North Bengal University (NBU)
M.Sc (Physiology): West Bengal University(WBSU)
Joined lab in 2017
Khusnood Fatma

B.Sc, Physiology,University of Calcutta
M.Sc.Physiology, University of Calcutta
Joined lab in 2017
Ananta Gorai

B.Sc,Kalyani University, 2015
Int. Ph.D. (Chemical science) IACS, Kolkata, 2017
Joined lab in 2017
Soumya Basak

Joined lab in 2019
Nabin Parui

B. Sc. (Chemistry), University of Burdwan
Joined lab in 2020
M. Sc. (Chemistry), University of Burdwan
Binayak Lala

B.Sc (Chemistry) Jadavpur University, 2017
M.Sc (Organic Chemistry) Jadavpur University, 2019
Joined lab in 2020

B.Sc (Chemistry), St. Paul's Cathedral Mission College, 2017.
MS (Chemical Sciences), IISc Bangalore, 2020.
Joined lab in 2020




128) Potassium tert-Butoxide Mediated Cascade Synthesis of Rutaecarpine Alkaloid Analogs: Access to Molecular Complexity on Multigram Scales" 

S. Basak, J. Dash*, Journal of Organic Chemistry, 2023 (accepted).


127) Bioorthogonal Chemistry in Translational Research: Advances and Opportunities”

R. Chaudhuri, S. Bhattacharya, J. Dash*, ChemBioChem, 2023, (accepted).

126) Nucleoside Derived Metallo-hydrogel Induces Cell Death in Leishmania Parasites,

S. Bhattacharya, T. Bhattacharyya, S.  Khanra, R.  Banerjee, J. Dash*ACS Infectious Diseases, 2023 (accepted).


125) KOtBu-Mediated Regioselective Hydroxymethylation of Thiazoles and Benzothiazoles: Synthesis of Biologically Active Heteroaromatic Compounds,

S. Karmakar,  D. Yadav,  J. Dash*Asian J. Org. Chem. 2023 (accepted).

124) "Nucleic Acids as Templates and Catalysts in Chemical Reactions: Target-guided Dynamic Combinatorial Chemistry

and In situ Click Chemistry and DNA/RNA Induced Enantioselective Reactions,

P. Saha, D. Panda, J. Dash*Chemical Society Reviews, 2023,  (accepted).


123) "Bisindole Enyne as a New Pharmacophore with Anticancer Properties,G. C. Midya, S. Mandal, J. Dash*,

 J. Indian Chem. Soc., 2023,  (invited article).


122) "Rapid Access to Substituted Indenones via Grignard Reaction and its Application in the Synthesis of

Fluorenones using Ring Closing Metathesis" 

N. Parui, T. Mandal, J. Dash*European Journal of Organic Chemistry, 2023 (accepted).


121) "Expanding the Toolbox of Target Directed Bio-Orthogonal Synthesis: In Situ Direct Macrocyclization by DNA Templates" 

R.  Chaudhuri, P.Thumpati, J. Dash*Angew. Chem. Int. Ed.. 202210.1002/anie.202215245 and

10.1002/ange.202215245. (front cover, appeared in Hot Topic: Bioorthogonal Chemistry).

 Highlighted in Nature India; 




120) "Diastereoselective Reversible C-C Bond Exchange of Oxindole-Thiazolidinediones for Dynamic Combinatorial Chemistry"

 A. Gorai, G. Chakraborti,  S. Basak,  J. Dash*Organic & Biomolecular Chemistry202220, 9307-9312.


119) "Thiazole Containing PNA Mimic Regulates c-MYC Gene Expression through DNA G-quadruplex" 

A. Gorai, R.  Chaudhuri, T. K. Mukhopadhyay, A. Datta,  J. Dash*Bioconjugate Chemistry 2022, 33, 6, 1145–1155.


118) Cycloaddition of N-sulfonyl and N-sulfamoyl azides with alkynes in aqueous media for the

selective synthesis of 1,2,3-triazoles, P.Thumpati, G. Chakraborti, T. Mandal, V. Ravichandiran, J. Dash*

Green Chemistry2022, 24, 911-915.


117) Ring closing metathesis for the construction of carbazole and indole-fused natural products

T. Mandal, J. Dash*, Organic & Biomolecular Chemistry, 2021, 19, 9797-9808 (perspective).


116) "Triazolyl Dibenzo[a,c]phenazines Stabilize Telomeric G-quadruplex and Inhibit Telomerase",

S. Pal, K. Fatma, V. Ravichandiran, J. Dash*, Asian J. Org. Chem. 2021, 10, 2921-2926.


115) "Potassium tert-Butoxide Promoted Synthesis of Dihydroquinazolinones",

T. Ghosh, I. MANDAL, S. Basak,  J. Dash*, J. Org. Chem. 2021, 86, 14695-14704. Highlighted in SYNFACTS (Synfacts 2022, 10.1055/s-0041-1737738) and Organic Chemistry Portal (


 114) "Studies Directed towards the Synthesis of Acridone Family of Natural Products:Total Synthesis of Acronycines and

Atalaphyllidines" T. Mandal, S. Karmakar, A. Kapat, J. Dash*ACS Omega, 2021, 6, 27062-27069.


113) A [3+2] Cycloaddition-1,2-Acyl Migration-Hydrolysis Cascade for Regioselective Synthesis of 1,2,3-Triazoles in Water, 

G. Chakraborti, T. Mandal, C. P. Roy, J. Dash*Chemical Communications, 2021, 57, 7970-7973.


112) “Binding Insights into Quadruplex Selective Carbazole Ligands”

D Müller, P Saha, D. Panda, J. Dash,* H Schwalbe*, Chemistry–A European Journal, 2021, 27, 12726-12736.  (Minireview).


111) “G4 Sensing Pyridyl-thiazole Polyamide Represses c-KIT Expression in Leukemia Cells”  

R. Paul, D. Dutta, T. Das, M. Debnath, J. Dash*, Chemistry - A European Journal, 2021, 27, 8590-8599. DOI:10.1002/chem.202100907.


110) Supramolecular Template Directed In Situ Click Chemistry: A Bio-inspired Approach to Synthesize

G-quadruplex DNA Ligands, T. Bhattacharyya, D. Panda, J. Dash*, Organic Letters2021, 23, 3004-3009.


109) Nucleic acid secondary structures for therapeutic and biomolecular device applications

S Bhattacharya, J. Dash*, Chem. Sci. Rep., 2021, (Invited Review Article).


108) Prolinamide plays a key role in promoting copper-catalyzed cycloaddition of azides and alkynes in aqueous media

via unprecedented metallacycle intermediates; G. Chakraborti, R. Jana, T. Mandal, A. Datta,* J. Dash*, 

Organic Chemistry Frontiers202182434-2441.


107) “Regulation of Gene Expression by Targeting DNA Secondary Structures"

R. Chaudhuri, K. Fatma, J. Dash*, Journal of Chemical Sciences. 2021,133(perspective).


106) “A DNA nanosensor for monitoring ligand-induced i-motif formation”

P. Saha, D. Panda, R. Paul, J. Dash*, Organic & Biomolecular Chemistry2021, 19, 1965-1969. DOI: 10.1039/D1OB00248A.


105) "Site-selective Aerobic C–H Mono-Acylation of Carbazoles Using Palladium Catalysis" 

 S. Maiti, T. Mandal, B. Dash, J. Dash*, J. Org. Chem. 2021, 86, 1396-1407.


104) "Recent Update on Targeting c‐MYC G‐Quadruplexes by Small Molecules for Anticancer Therapeutics"

R. Chaudhuri, S. Bhattacharya, J. Dash,* S. Bhattacharya*, J. Med. Chem. 2021, 64, 42-70.  (perspective).


103) “Domino Relay Olefin Metathesis of Triallyl Oxindole and Indole Precursors to Access Cyclic Indoxyls and Carbazoles” 

T. Mandal,  K. Dhar, N. Parui, J. Dash*, ChemCatChem, 202012, 4754–4759. (This publication is part of a Special Collection on “The Catalysis of Ring Synthesis).

102) "Carbon dot cross-linked gelatin nanocomposite hydrogel for pH-sensing and pH-responsive drug delivery"

SK Bhattacharyya, M Dule, R Paul, J Dash, M Anas, TK Mandal, P Das,

ACS Biomaterials Science & Engineering2020, 6, 5662-5674.


101) In vivo experiments demonstrate the potent antileishmanial efficacy of repurposed suramin in visceral leishmaniasis,

S. Khanra,S. Kumar Juin,J. J. Jawed,S. Ghosh,S. Dutta,S. A. Nabi, J. Dash, D. Dasgupta,S. Majumdar, R. Banerjee, 

PLOS Neglected Tropical Diseases2020, doi: 10.1371/journal.pntd.0008575


100)  "Target Directed Azide-Alkyne Cycloaddition for Assembling HIV-1 TAR RNA Binding Ligands";

R. Paul, D. Dutta, R. Paul, J. Dash* Angew. Chem. Int. Ed.. 2020DOI: 10.1002/anie.202003461 and 10.1002/ange.2020034.


99) "Reductive aromatization of oxindoles to 3-substituted indoles"

T. Mandal, G. Chakraborti, J. Dash*Tetrahedron Letters, 2020, 61..

98) "Click and combinatorial approaches to quadruplex ligand discovery" J. Dash*, P. Saha , K. Fatma,

Annual Reports in Medicinal Chemistry, Volume xx © 2020; ISSN 0065-7743,S. Neidle, Editor. (book chapter),  


97) "In situ Formation of Transcriptional Modulators using Non-canonical DNA i-Motifs" P. Saha, D. Panda, D. Müller, A. Maity, H. Schwalbe, J. Dash*, Chemical Science 2020, (inside back cover).

96) "Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion

across biological membranes" M. Debnath, S. Chakraborty, Y. P. Kumar, R. Chaudhuri, B. Jana,  J. Dash*,

 Nature Communications, 2020, 11.

95) "A G-quadruplex Specific Cell-Permeable Guanosine-Anthracene Conjugate Inhibits Telomere Elongation and Induces Apoptosis by Repressing c-MYC Gene"

P. Saha, Y. P. Kumar, T. Das, D.  Müller, I. Bessi, H. Schwalbe,  J. Dash*,  Bioconjugate Chemistry 201930, 3038-3045.

94) "G‐quadruplex Binding Small Molecule Induces Synthetic Lethality in Breast Cancer Cells by Inhibiting c‐MYC and BCL2 Expression" R. Paul, T. Das, M. Debnath, A. Chauhan, J. Dash*, ChemBioChem, 2019, 21, 963-970.

93) "Domino Grignard Addition and Oxidation for the One-Pot Synthesis of C2-Quaternary 2-Hydroxyindoxyls" T. Mandal, G. Chakraborti, S. Maiti, J. Dash*, Organic letters, 2019 21, 8044-8048.

92) "Ring Closing Metathesis Approach for the Synthesis of o‐Terphenyl Derivatives"  S Karmakar, T Mandal, J. Dash*, European Journal of Organic Chemistry 2019, 5916-5924.

91) "KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines" T Ghosh, S Jana, J. Dash*, Organic letters, 2019, 21, 6690-6694. highlighted in Organic Chemistry Portal;

90) "Cytidine-Derived Hydrogels with Tunable Antibacterial Activities"  T Bhattacharyya, R Chaudhuri, KS Das, R Mondal, S Mandal, J. Dash*, ACS Applied Bio Materials, 2019, 2, 3171-3177.

89) "Chemical Regulation of DNA i-Motifs for Nanobiotechnology and Therapeutics" M. Debnath, K. Fatma, J. Dash*, Angew. Chem. Int. Ed. 2019, 57, 2942-2957.

88) “The application of click chemistry for targeting quadruplex nucleic acids” P. Saha, D. Panda, J. Dash*, Chem. Commun. 2019, 55, 731-750.


87) "A Competitive Pull-down Assay Using G-quadruplex DNA Linked Magnetic Nanoparticles to Determine Specificity of G-quadruplex Ligands" D. Panda, P. Saha, R. Chaudhuri, P. Thumpati, Y.  Ravichandiran, J. Dash*, Analytical Chemistry, 2019, 91, 12, 7705-7711.

86) "Dynamic Generation of G-quadruplex DNA Ligands by Target-Guided Combinatorial Chemistry on a Magnetic Nano-platform" S.Jana, D. Panda, P. Saha, D. Pantos, J. Dash*, J. Med. Chem. 2019, 62, 762-773. Highlighted in nature INDIA, Magnetic nanotemplate for developing anticancer drugs, doi:10.1038/nindia.2019.5.

85) Microwave assisted cross-coupling reactions using palladium nanoparticles in aqueous media, K. Dhara, B. Parasar, A. J. Patil, J. Dash*, Synthetic Communications, 2019, 1-10.

84) "Guanosine derived supramolecular hydrogels: Recent developments and future opportunities" T. Bhattacharyya, P. Saha, J. Dash*, ACS Omega, 20183, 2230–2241.

83) "Divergent and Orthogonal Approach to Carbazoles and Pyridoindoles from Oxindoles via Indole Intermediates" T. Mandal, G. Chakraborti, S. Karmakar, J. Dash*, Org. Lett. 2018, 20, 4759−4763.

82) "Small Molecule Driven Stabilization of Promoter G-quadruplexes and Transcriptional Regulation of c-MYC", T. Das, D. Panda, P. Saha, J. Dash* Bioconjugate Chemistry 2018, 29, 2636.

81) "Cell Penetrating Thiazole Peptides Inhibit c-MYC Expression via Site-Specific Targeting of c-MYC G-quadruplex" D. Dutta,  M. Debnath, D. Müller, R. Paul, T. Das, I. Bessi, H. Schwalbe,  J. Dash* Nucleic Acids Research 2018, 46, 5355-5365.

80) “In vitro screening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin”S Khanra, YP Kumar, J Dash, R Banerjee, BMC research notes 2018, 11, 319.

79) "Enzyme-regulated DNA-based logic device" M. Debnath, R. Paul, D. Panda, J. Dash* ACS Synthetic Biology 2018, 7, 1456-1464. Highlighted in the Hindu; Highlighted in Nature India,

78) "Design and synthesis of novel polyamine collector to recover iron values from iron ore slimes" A. S. Patra, N. V. R. Nulakani, Y. P. Kumar, V. Subramanian, J Dash, A. K. Mukherjee, Powder Technology, 2018, 325, 180-191.

77) "Human telomeric G-quadruplex selective fluoro-isoquinolines induce apoptosis in cancer cells" S. Maiti, P. Saha, T. Das, I. Bessi,H. Schwalbe, J. Dash*, Bioconjugate Chemistry, 2018, 29, 1141-1154.

76) "Self-assembly of a Guanosine Derivative to Form Nanostructures and Transmembrane Channels" R. N. Das,Y. P. Kumar, S. A. Kumar,O. M. Schütte,C. Steinem, J. Dash* Chemistry-A European Journal, 2018, 24, 4002-4005.

75) “On Water’’ promoted Ullmann type C-N bond forming reactions: Application to carbazole alkaloids by selective N-arylation of aminophenols, G. Chakraborti, S. Paladhi, T. Mandal, J. Dash*, Journal of Organic Chemistry201883, 7347-7359 (special issue on 'Organic & Biocompatible Transformations in Aqueous Media'); highlighted in Organic Chemistry Portal;

74) "Supramolecular hydrogel inspired from DNA structures mimics peroxidase activity" T. Bhattacharyya, Y. P. Kumar, J. Dash*, ACS Biomaterials Science & Engineering, 2017, 3, 2358-2365.

73) "Preferential targeting of i-motifs and G-quadruplexes by small molecules", M. Debnath, S. Ghosh, A. Chauhan, R. Paul, K. Bhattacharyya, J. Dash*, Chemical Science 2017, 8, 7448-7456.

72) "Zinc-mediated efficient and selective reduction of carbonyl compounds", T. Mandal, S. Jana, J. Dash*, European Journal of Organic Chemistry, 2017, 4972-4983.

71) "Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor", D. Panda, P. Saha, T. Das, J. Dash*, Nature communications, 20178, 16103.

Highlighted in The Hindu,


70) "Palladium-catalyzed pyridine-directed regioselective oxidative C–H acylation of carbazoles by using aldehydes as the acyl source", S. Maiti, L. Burgula, G. Chakraborti, J. Dash*, European Journal of Organic Chemistry, 2017, 332-340.

69) "Bipyridine facilitates regioselective dimerization of alkynes in the absence of transition metal", G. C. Midya,B. Parasar, S. Maiti, J. Dash* ChemistrySelect20172, 5032-5037.

68) "Amino acid derived naphthalenediimides as versatile G-quadruplex binders", D. M. Rasadean, B. Sheng, J. Dash, G. D. Pantos*, Chemistry-A European Journal, 201723, 8491-8499.

67) "Functional architectures derived from guanine quartet" J. Dash*, P. Saha, Organic & Biomolecular Chemistry 2016,14, 2157-2163.

66) "Targeting G-quadruplex with small molecules: An NMR view" I, Bessi, J. Wirmer-Bartoschek, J. Dash, H. Schwalbe, Modern Magnetic Resonance: 2nd edition, 2017, 1-22. doi:10.1007/978-3-319-28275-6_126-1.

65) Chiral carbon dots derived from guanosine 5'-monophosphate form supramolecular hydrogels", A. Ghosh, B. Parasar, T. Bhattacharyya, J. Dash*, Chemical Communications 201652, 11159-11162.

64) "Synthesis of magnetic nanoparticles and polymer supported imidazolidinone catalysts for enantioselective Friedel-Crafts Alkylation of Indoles", S. Pagoti, T. Ghosh, J. Dash*, ChemistrySelect, 20161, 4386-4391.

63) "Synthesis of fluorescent binaphthyl amines that bind c-MYC G-quadruplex DNA and repress c-MYC expression," A. Chauhan, R. Paul, M. Debnath, I. Bessi, S. Mandal, H. Schwalbe, J. Dash*, Journal of Medicinal Chemistry, 201659, 7275-7181.

62) "Transition metal-free terminal alkyne addition to isatins", K. Dhara, A. Kapat,T. Ghosh, J. Dash*, Synthesis, 201648, 4260-4268.

61) "Small molecule regulated dynamic structural changes of human G-quadruplexes" M. Debnath, S. Ghosh, D. Panda, I. Bessi, H. Schwalbe, K. Bhattacharyya, J. Dash*, Chemical Science, 20167, 3279-3285.

60) “Bis-triazolyl diguanosine derivatives as synthetic transmembrane ion channels” Y. P. Kumar, R. Nath Das, O. M. Schütte, C. Steinem*, J. Dash*, Nature Protocols, 201611, 1039-1056.

59) “Selective recognition of c-MYC G-quadruplex DNA using prolinamide derivatives" A. Chauhan, S. Paladhi, M. Debnath, J. Dash*, Organic & Biomolecular Chemistry, 2016, 14, 5761-5767. (Invited article for New Talent Themed Issue).

58) "Fluorescent dansyl-guanosine conjugates that bind c-MYC promoter G-quadruplex and downregulate c-MYC expression" Y. P. Kumar, P. Saha, D. Saha, I. Bessi, H. Schwalbe, S. Chowdhury, J. Dash*, ChemBioChem. 201617, 388-393.

57) "Synthesis of carbazole alkaloids by ring-closing metathesis and ring rearrangement–aromatization", K. Dhara, T. Mandal. J. Das, J. Dash* Angewandte Chemie International Edition, 2015, 54, 15831-15835. 

56) "A nucleus-imaging probe that selectively stabilizes a minor conformation of c-MYC G-quadruplex and down-regulates c-MYC transcription in human cancer cells." D. Panda, M. Debnath, S. Mandal, I. Bessi, H. Schwalbe, J. Dash*, Scientific Reports20155, 13183.

55) "A DNA-inspired synthetic ion channel based on G−C base pairing", R. N. Das, Y. P. Kumar, O. M. Schütte, C. Steinem,* J. Dash*, Journal of the American Chemical Society, 2015, 137, 34–37. (9) Highlighted in nature INDIA;

54) “Transition-metal free hydration of nitriles using potassiumtert-butoxide under anhydrous conditions” G. C. Midya, A. Kapat, S. Maiti, J. Dash,* Journal of Organic Chemistry, 2015, 80, 4148–4151. (19) Highlighted in Organic Chemistry Portal,

53) “C3-Symmetric pyridine and bipyridine derivatives: Simple preparation by cyclocondensation and 2D self-assembly at a solution-graphite interface” J. Dash, D. Trawny, J. P. Rabe, H.-U. Reissig,* Synlett, 2015, 26, 1486–1489.

52) "Environment-sensitive probes containing a 2,6-diethynylpyridine motif for fluorescence turn-on detection and induction of nanoarchitectures of human telomeric quadruplex" R. N. Das, M. Debnath, A. Gaurav, J. Dash,* Chemistry-A European Journal, 2014, 20,16688-16693.

51) "Asymmetric aldol reaction of thiazole carbaldehydes: Regio and stereoselective synthesis of tubuvalin analogues" S. Paladhi,J. Das, M. Samanta, J. Dash*, Advanced Synthesis & Catalysis2014356, 3370-3376.

50) “A small molecule peptidomimetic that binds to c-KIT1 G-quadruplex and exhibits antiproliferative properties in cancer cells” A. Chauhan, S. Paladhi, M. Debnath, S. Mandal, R. Nath Das, S. Bhowmick, J. Dash*, Bioorganic & Medicinal Chemistry, 201422, 4422–4429.

49) “Triazole tailored guanosine dinucleosides as biomimetic ion channels to modulate transmembrane potential” Y. P. Kumar, R. Nath Das, S. Kumar, O. M. Schütte, C. Steinem,* J. Dash* Chemistry-A European Journal, 201420, 3023-3028.

(Highlighted in Chemistry views magazineHighlighted in nature INDIA)

48) “Thiazolidinedione-isatin conjugates via an uncatalyzed diastereoselective aldol reaction on-water S. Paladhi, M. Bhati, D. Panda, J. Dash*, Journal of Organic Chemistry, 2014, 79, 1473-1480.

47) “Ligand mediated facile iron catalyzed dimerization of terminal aryl alkynes” G. C. Midya,B. Parasar,K. Dhara, J. Dash,* Organic & Biomolecular Chemistry, 2014,121812-1822.

46) “A magnetoclick imidazolidinone nanocatalyst for asymmetric 1,3-dipolar cycloaddition” S. Pagoti, D. Dutta, J. Dash,* Advanced Synthesis & Catalysis 2013, 355, 3532–3538. 

Highlighed in Synfacts, 2014, 10, 0329.

45) A fluorescent guanosine dinucleoside as a selective switch-on sensor for c-myc G-quadruplex DNA with potent anticancer activities" Y. P. Kumar, S. Bhowmik, R. N. Das, I. Bessi, S. Paladhi, R. Ghosh, H. Schwalbe, J. Dash*, Chemistry-A European Journal, 2013, 19, 11502–11506. (appeared as inside cover page).

44) “Design and synthesis of an ON-OFF “click” fluorophore that executes a logic operation and detects heavy and transition metal ions in water and living Cell” G. C. Midya, S. Paladhi, S. Bhowmick, S. Saha, J. Dash*, Organic & Biomolecular Chemistry, 201311, 3057-3063.

43) “pH Dependent multifunctional and multiply-configurable logic gate systems based on small molecule G-quadruplex DNA recognition” S. Bhowmik,R. N. Das,B. Parasar, J. Dash* Chemical Communications, 2013, 49, 1817-1819.

42) “Reduction of organic azides to amines using reusable Fe3O4 nanoparticles in aqueous medium” S. Pagoti, S. Surana, A. Chauhan, B. Parasar, J. Dash*, Catalysis Science & Technology, 2013, 3, 584-588.

41) “Multifunctional “click” prolinamides: A new platform for asymmetric Aldol reaction in the presence of water with catalyst recycling” S. Paladhi, J. Das, P. K. Mishra, J. Dash*, Advanced Synthesis & Catalysis, 2013355, 274-280.

40) "An Uncatalyzed Aldol Reaction of Thiazolidinediones" S. Paladhi, A. Chauhan, K. Dhara, A. K. Tiwari, J. Dash,* Green Chemistry, 2012, 14, 2990-2995. 

39) "A diversity oriented approach to spirocyclic and fused hydantoins via olefin metathesis" K. Dhara, G. C. Midya, J. Dash*, Journal of Organic Chemistry, 2012, 77, 8071-8082. 

38) "Diffusion and Birefrengence of Bioactive Dyes in a Guanosine Supramolecular Hydrogel" R. N. Das,Y. P. Kumar, S. Pagoti, A. J. Patil, J. Dash*, Chemistry-A European Journal, 2012,18, 6008-6014.

37) "Synthesis of Bis-indole Carboxamides as G-quadruplex Stabilizing and Inducing Ligands" J. Dash*, R. N. Das, N. Hegde, G. D. Pantos, P. S. Shirude, S. Balasubramanian,* Chemistry-A European Journal, 2012,18, 554-564.

36) "Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)- melithiazole G and (14S) cystothiazole" A. Colon, T. J. Hoffman, J. Gebauer, J. Dash, J. H. Rigby, S. Arseniyadis, J. Cossy, Chemical Communications, 201248, 10508-10510. 

35) "Iron catalyzed highly regioselective dimerization of terminal aryl alkynes" G. C. Midya, S. Paladhi, K. Dhara, J. Dash,* Chemical Communications, 201147, 6698-6700.

34) "Synthesis of spirocyclic thiazolidinedione derivatives using ring-closing metathesis and one pot sequential ring-closing/cross metathesis” K. Dhara, S. Paladhi, G. C. Midya, J. Dash,* Organic & Biomolecular Chemistry, 2011, 9, 3801-3807.

33) "A supported palladium nanocatalyst for copper free acyl Sonogashira reactions: One-pot multicomponent synthesis of N-containing heterocycles" S. Santra, K. Dhara, P. Ranjan, P. Bera, J. Dash,* S. Mandal,* Green Chemistry201114, 3238-3247.

32) "Modulation of small molecule induced architecture of cyclodextrin aggregation by guest structure and host size" P. Ghosh, A. Maity, T. Das, J. Dash*, P. Purkayastha,* J. Phys. Chem. C, 2011,115, 20970–20977.

31) "Interaction of a new surface sensitive probe compound with anionic surfactants of varying hydrophobic chain length" A. Maity, P. Ghosh, T. Das, J. Dash,* P. Purkayastha,* J. Colloids Interface Sci. 2011364, 395-399.

30) "Supramolecular hydrogels derived from silver ion-mediated self-assembly of 5'-guanosine monophosphate" J. Dash, A. J. Patil, R. N. Das, F. L. Dowdall, S. Mann,* Soft Matter20117, 8120-8126.

29) "Synthesis and binding studies of novel diethynyl-pyridine amides with genomic promoter DNA G-quadruplexes" J. Dash,* Z. A. E. Waller, G. Dan Pantos, S. Balasubramanian,* Chemistry-A European Journal, 2011, 17, 4571-4581.

28) "G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells" K. I. E. McLuckie, Z. A. E. Waller, D. A. Sanders, D. Alves, R. Rodriguez, J. Dash, G. J. McKenzie, A. R. Venkitaraman, S. Balasubramanian,* Journal of the American Chemical Society, 2011133, 2658-2663.

27) "A concise approach towards the synthesis of WS75624 A and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles" J. Dash, B. Melillo, S. Arseniyadis, J. Cossy,* Tetrahedron Letters, 2011, 52, 2246-2249.

26) "A three-component synthesis of β-alkoxy β-keto-enamides—flexible precursors for 4-hydroxypyridine derivatives and their palladium-catalysed reactions"; T. Lechel, J. Dash, C. Eidamshausa, I. Brüdgam, D. Lentza, H.-U.Reissig,* Organic & Biomolecular Chemistry, 2010, 8, 3007-3014.

25) "Three-component synthesis of perfluoroalkyl- or perfluoroaryl-substituted 4-hydroxypyridine derivatives and their palladium-catalyzed coupling reactions" T. Lechel, J. Dash, P. Hommes, D. Lentz, H.-U. Reissig,* Journal of Organic Chemistry 201075, 726–732.

24) "A new and flexible synthesis of 4-hydroxypyridines: Rapid access to Caerulomycins A, E and functionalized terpyridines" J. Dash, H.-U. Reissig,* Chemistry-A European Journal 200915, 6811-6814.

23) "Enantioselective organocatalytic conjugate reduction of β-azole α,β-unsaturated aldehydes" T. J. Hoffman, J. Dash, J. H. Rigby, S. Arseniyadis, J. Cossy,* Organic letters, 2009, 11, 2756-2759.

22) "Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes" J. Dash, P.S. Shirude, S.-T.D. Hsu, S. Balasubramanian,* Journal of the American Chemical Society 2008130, 15950–15956.

21) "G-Quadruplex recognition by bis-indole carboxamides" J. Dash, P.S. Shirude, S. Balasubramanian,* Chemical Communications2008, 3055–3057.

20) "Novel furopyridine derivatives via Sonogashira reactions of functionalized pyridines" T. Lechel, J. Dash, I. Brüdgam, H.-U. Reissig*, European Journal of Organic Chemistry, 2008, 21, 3647-3655.

19) "Crystal structure of 1,4-bis[3-methoxy-4-(4-methoxyphenyl)-6- (trifluoromethyl)pyridi 2yl]benzene, C34H26F6N2O4J. Dash, I. Brüdgam, H. Hartl, H.-U. Reissig,* Z. Kristallogr. NCS 2008223, 347–348.

18) "Synthesis of vinyl-functionalized thiazoles by cross-metathesis and tandem Stille coupling/cross-metathesis" J. Dash, S. Arseniyadis, J. Cossy,* Advanced Synthesis & Catalysis, 2007349, 152–156.

17) "Scope of a novel three-component synthesis of highly functionalized pyridines" J. Dash, T. Lechel, H.-U. Reissig,* Organic Letters, 20079, 5541-5544.

Highlighted in Synfacts; Three-Component Synthesis of Functionalized PyridinesSynfacts 2008 (3), 0245-0245

16) "Concise synthesis of novel oxa-bridged compounds" F. A. Khan,* J. Dash, Ch. Sudheer, N. Sahu, P. Karuppasamy, Journal of Organic Chemistry, 2005, 70, 7565–7577.

15) "A new color of the synthetic chameleon methoxyallene: A novel synthesis of trifluoromethyl-substituted pyridinol derivatives–an unusual reaction mechanism, a remarkable crystal packing and first palladium-catalyzed coupling reactions" O. Flögel, J. Dash, I. Brüdgam, H. Hartl, H.-U. Reissig,* Chemistry-A European Journal, 2004, 10, 4283–4290.

14) "Hydrotalcite catalysis in ionic liquid medium: A recyclable reaction system for heterogeneous knoevenagel and nitroaldol condensation" F.A. Khan,* J. Dash, R. Satapathy, S. K. Upadhyay, Tetrahedron Letters, 2004, 45, 3055–3058.

13) "Indium-mediated regio- and diastereoselective reduction of norbornyl α-diketones" F. A. Khan, J. Dash, Ch. Sudheer, Chemistry-A European Journal 2004, 10, 2507–2519.

12) "Diastereoselection during allylindium addition to norbornyl α-diketones" F. A. Khan,* J. Dash, European Journal of Organic Chemistry 2004, 12, 2692–2700.

11) "A Rapid and stereoselective route to trans-hydrindane ring system" F. A. Khan,* R. Satapathy, J. Dash, G. Savitha, Journal of Organic Chemistry 2004, 69, 5295–5301.

10) "A short and stereoselective synthesis of functionalized pentenomycin derivatives" F.A. Khan,* J. Dash, B. Rout, Tetrahedron Letters, 2004, 45, 9285–9288.

9) "A novel and expeditious approach to unusual spiro lactam building blocks" F. A. Khan,* J. Dash, Journal of Organic Chemistry, 200368, 4556–4559. 

8) "Chemoselective reduction of aromatic nitro compounds in ionic liquids using Zinc and ammonium salts; F. A. Khan,* J. Dash, Ch. Sudheer, R. K. Gupta, Tetrahedron Letters, 2003, 44, 7783–7789. 

7) An easy access to γ-lactone-fused cyclopentanoids; F. A. Khan,* J. Dash, N. Sahu, Ch. Sudheer, Journal of Organic Chemistry, 2002, 67, 3783–3787. 

6) Regio- and diastereoselective reduction of non-enolizable α-diketones to acyloins mediated by indium metal; F. A. Khan,* J. Dash, N. Sahu, S. Gupta, Organic Letters, 2002, 4, 1015–1018.

5) Synthesis of a novel, highly symmetric bis-oxa-bridged compound; F.A. Khan,* J. Dash, Journal of the American Chemical Society 2002, 124, 2424–2425. 

4) Synthesis of Novel Caged Bishemiacetals and their Facile Conversion to Symmetric Bis-α-halo-γ-lactones; F. A. Khan,* N. Sahu, J. Dash, and B. Prabhudas, Journal of the Indian Institute of Sciences 2001, 81, 325–331.

3) Rearrangement of 1,4,5,6-Tetrahalo-7,7-dimethoxybicyclo[2.2.1]hept-5-ene-2-one to Phenolic Derivatives; F. A. Khan,* J. Dash, D. Jain, and B. Prabhudas, J. Chem. Soc., Perkin Trans. 1, 2001, 3132–3134. 

2) "1,2,3,4-Tetrachloro-5,5-dimethoxy-cyclopenta-1,3-diene: Diels-Alder reactions and applications of the products formed" F. A. Khan,* B. Prabhudas, J. Dash, Advanced Synthesis & Catalysis 342, 512–517.

1) A ruthenium catalyzed, novel and facile procedure for the conversion of vicinal dihaloalkenes to α-diketones; F. A. Khan,* B. Prabhudas, J. Dash, N. Sahu, Journal of the American Chemical Society 2000, 122, 9558–9559.
















Open Positions

Motivated candidates having MSc degree in Chemistry/Biology with INSPIRE/CSIR fellowships can directly contact Dr. Jyotirmayee Dash (ocjd@iacs.res.infor PhD positions.


Project Students Alumni

Current project students     

      1. Thumpati Prasanth (NIPER Kolkata)

      2. Sarmistha Pal (NIPER Kolkata)

      3. Rubi Roy (MS.PhD-IACS)-M.Sc Project

      4. Deepak Yadav (MS.PhD-IACS)-M.S. Project

      5. Arkaprovo Sarkar (MS.PhD-IACS)-M.S. Project 

      6. Sathis Bhukya  (NIPER Kolkata)-MS Pharma Project


      Former Project Students:

       1. Abhiket Gaurav (IISER-K)-5th year MS Project

       2.  Sonu Kumar (IISER-K)-5th year MS Project

       3. Pratyush Kumar Mishra (IISER-Pune)-Summer Project

       4. Meeta Bhati (Central University of Rajasthan)-Summer Project

       5. Bibudha Parasar (IISER-K)-Summer Project

       6.  Subham Surana (Delhi University)--IAS Summer Fellow

       7.  Sharmistha De (University of Calcutta)-Summer Project

       8.  Sukanta Koley (RMVC College)-Summer Project

       9. Palash Banerjee (RKMRC)-DST-INSPIRE Summer Fellow

      10.  Madhvi Gupta (Ramjas College)-IAS Summer Fellow

      11. Animesh Biswas (RKMV)-Summer Project, DST-Inspire

      12. Sreemantula Arun Kumar (NIPER-K)-MS (Pharm) Project

      13. Sourajit Bera (RKMV)-DST-INSPIRE Summer Fellow

      14. Susobhan Swain (VSSUT, Burla)-IAS Summer Fellow

      15. Antara Mukharjee (Presidency University)-MS (Biochemistry) Project

      16. Debolina Sarkar (Jadavpur University)- Summer Project

      17. Shrestha Banerjee (Presidency University)- Summer Project

      18. Divine P Daniel (NIPER-K)-MS (Pharm) Project

      19. Thumpati Prasanth (NIPER-K)-MS (Pharm) Project

      20. Abhik Paul (NIPER-K)-MS (Pharm) Project

      21. Javaji Anuradha (NIPER-K)-MS (Pharm) Project

      22. Ravuri Subba rao (NIPER-K)-MS (Pharm) Project

      23. Kaustav Saha (WBUT)-Summer Project


2023    OPPI Scientist of the Year

2023    Prof. K. N. Ganesh Endowment Lecture, KNG Trust

2023    Featured in Vigyan Vidushi, 75 Women Trailblazers of Science, a Brochure on Indian Women Scientists by Vigyan Prasar

2022    Professor P K Bose Memorial Award Lecture, Indian Chemical Society

2022    Featured in the 75 under 50: Scientists Shaping Today's India,

A compendium released by the Department of Science and Technology, Ministry of Science and Technology

2021    Featured as Asia's Rising Scientists 100, Asian Scientist Magazine

2021    Elected Fellow of the Indian Academy of Sciences (IASc), Bangalore

2020    Shanti Swarup Bhatnagar Prize for Science and Technology in Chemical Sciences by the Council of Scientific and Industrial Research (CSIR), Government of India

2020    Fellow of the Royal Society of Chemistry, FRSC

2020    Bronze Medal, Chemical Research Society of India (CRSI)

2020    Wellcome Trust/DBT India Alliance Senior Fellowship Award

2019    Second Charusita Chakravarty Memorial Lecture, Chemical Research Society of India (CRSI)

2015-2016       SwarnaJayanti Fellowship, Department of Science and Technology

2007-2009       Marie-Curie Fellowship, University of Cambridge, UK

2004-2006       Alexander von Humboldt Fellowship, F. U. Berlin, Germany


Editorial Advisory Board Member of Journals:

ACS Bioconjugate Chemistry, since 2022

ACS Omega since 2021

Asian JOC, 2021

Chemical Communications, 2020

Sectional editor (Organic and Biomolecular Chemistry):

Journal of the Indian Chemical Society, since 2022



Dr. Rabindra Nath Das

Received Ph.D. Degree in September, 2014.
Currently working as Wenner-Gren Post-Doctoral Fellow, Department of Chemistry, Umeå University, Sweden.
Selected for 'IdEx Bordeaux Post-Doctoral Fellowship', European Institute of Chemistry and Biology (IECB), University of Bordeaux, France (2016-2017).
Dr. Sushovan Paladhi

Received Ph.D. Degree in September, 2014.
*Currently working as an Assistant Professor at Anugrah Narayan Singh College, Patna (Patliputra University, Patna). ( )
*Awarded Brain Korea 21 plus Postdoctoral Fellowship 2016-17 from, SKKU, Korea. 2016
*Selected for “SERB-Overseas Postdoctoral Fellowship 2015-16” by SERB, India (Declined), 2016
*Awarded 1st Prize of Lilly Outstanding Thesis Award from Eli Lilly and Company, USA. 2014
*Awarded for the best poster presentation on “Recent Trends in Research and Awarded 2nd prize for poster presentation in the “ICGC-2011” at CURAJ 2011
Dr. Ganesh Chandra Midya

Received Ph.D. Degree in April, 2015.
Currently working as an Assistant Professor at Ananda Chandra College, Jalpaiguri.
Dr. Kalyan Dhara

Received Ph.D. Degree in 2015.
Currently working as a Post Doctoral Research Fellow at Université de Bordeaux, France. Received 'IdEx Bordeaux fellowship' for postdoctoral research at Université de Bordeaux, France. (2018-2020) Received 'Kreitman fellowship' for postdoctoral research at Ben-Gurion University of the Negev, Israel. (2016-2018)
Dr. Sreenivasarao Pagoti

Received Ph.D. Degree in 2016.
Currently working as an Assistant Plant Protection Officer, Food Corporation
Dr. Ajay Chauhan

Received Ph.D. Degree in 2016.
Dr. Y. Pavan Kumar

Received Ph.D. Degree in 2016.
Currently working as a Post Doctoral Research Fellow at University of York, Heslington, UK.
Dr. Deepanjan Panda

Received Ph.D. Degree in 2018.
Post Doctoral Research Fellow at Minnesota, USA.
Currently working as a Post-Doctoral Fellow, Department of Chemistry, Technion-Israel Institute of Technology.
Dr. Manish Debnath

Received Ph.D. Degree in 2018.
Debasish Dutta

Academic Background
B. Sc. (Chemistry) Vidyasagar University
M. Sc. (Chemistry) IIT Guwahati
Thesis Submitted in 2019
Received Ph.D. Degree in 2020.
Subhadip Maiti

Academic Background
B.Sc. (Chemistry) Ramakrishna Mission Vidyamandira, Belur
Int. Ph.D. (Chemica science) (IACS)
Received Ph.D. Degree in 2020
Puja Saha

Academic Background
B. Sc. (Microbiology) University of Calcutta
M. Sc. (Microbiology) University of Calcutta
Received Ph.D. Degree in 2020
Newton International Fellowship 2020 for postdoctoral research at the University of Manchester, UK.
Tirtha Mandal

Academic Background
B. Sc. (Chemistry) Jadavpur University(2012)
M. Sc. (Chemistry) Jadavpur University(2014)
Joined the group in 2014
Received Ph.D. Degree in 2020
Currently working as a Post-Doctoral Fellow, Department of Chemistry, University of Regensburg, Germany.
Gargi Chakraborti

Academic Background
B. Sc. (Chemistry) Jadavpur University (2012)
M. Sc.(Chemistry) Jadavpur University (2014)
Joined the group in 2015
Received Ph.D. Degree in 2020
Currently working as a Post-Doctoral Fellow, Department of Chemistry, University of Regensburg, Germany.
Rakesh Paul

Academic Background
B. Sc. (Microbiology) WBSU
M. Sc. (Microbiology) WBSU
Joined the group in 2015
Received Ph.D. Degree in 2021
Tanima Bhattacharya

Academic Background
B. Sc. (Chemistry) University of Burdwan
M. Sc. (Chemistry) NIT Durgapur
Joined the group in 2015
Received Ph.D. Degree in 2021

Former Short-term Visitors and Research Associates:

1. Dr. Joydeb Das, Research Associate (Feb 2012-Jan 2016), Currently working as an Assistant Professor in Bagati Sree Gopal Banerjee College, Hoogly, West Bengal

2. Dr. Sudipta Bhowmick, Research Associate (Feb 2012-June 2013), Currently working as a DST-INSPIRE Faculty at University of Calcutta

3. Dr. Samir Mandal, Research Associate (July2013-Feb 2015), Currently working as an Assistant Professor at Govt. General Degree   College for Girls, Alipore, Kol-27

4. Dr. Ajoy Kapat, Research Associate (May 2014-Oct 2014), Currently working as an Assistant Professor in Shib Nadar University, Dadri, Uttar Pradesh

5. Dr. Anup Ghosh, Senior Research Associate (September 2015-June 2016),  Currently working as an DST-Inspire Faculty in S. N. Bose National Centre for Basic Sciences, Kolkata

6. Dr. Laxminarayana Burgula, Research Associate , Ph.D. IIT Guwahati (2015)